Genmab A+s

Stichting Sanquin Bloedvoorziening

Gemini Therapeutics Sub, Inc.

Ilse Jongerius

David Satijn

Sridhar Govindarajan

Marije Overdijk

Taco Willem Kuijpers

Maria Clara Brouwer

Richard Benjamin Pouw

Diana Wouters

Tom Purcell

Theodorus Sjouke Plantinga

Scott Lauder

Taede Rispens

Gillian Dekkers

Madelon Paauwe

Grietje Andringa

Bart Ecg De Goeij

Onno Wouter Kranenburg

Jamila Laoukili

The present invention relates to a multispecific antibody comprising at least a FAPα binding region comprising a first heavy chain variable region and a first light chain variable region; and a DR4 binding region comprising a second heavy chain variable region and a second light chain variable region. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

Antibodies binding to fibroblast activation protein alpha and death receptor 4

Provided herein are novel isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H, or nucleic acids or vectors encoding such antibodies and fragments. Further provided herein is the use of such antibodies, fragments, nucleic acids or vectors for inhibiting complement activation and treatment of disorders associated with complement activation.

Factor H potentiating antibodies and uses thereof

Growing community of inventors

De Bilt, Netherlands

Ilse Jongerius