Shizuoka University

Yamasa Corporation

Hirosaki University

Shizuoka Prefectural University Corporation

Shizuoka Prefectural Universities Corporation

Ilpal Jwa

Takashi Suzuki

Toshitada Noguchi

Tomoki Hamamoto

Chikara Ohyama

Tohru Yoneyama

Yuki Tobisawa

Yusuke Ohba

Taiichi Usui

Takeomi Murata

Shingo Hatakeyama

Maho Yamaguchi

The method for distinguishing between prostate carcinoma and benign prostatic hyperplasia comprising: bringing an analyte sample containing a prostate-specific antigen (PSA) into contact with a carrier having an anti-free PSA antibody immobilized thereon, thereby binding free PSA to the anti-free PSA antibody immobilized on the carrier; thereafter bringing the carrier in which the free PSA is bound to the immobilized anti-free PSA antibody into contact with a monoclonal antibody capable of specifically recognizing a glycan in which a terminal sialic acid residue is bound to galactose through an &#x3b1;(2,3) bond, thereby binding the monoclonal antibody recognizing the glycan to the free PSA bound to the anti-free PSA antibody; measuring the amount of the free PSA having an N-type glycan in which a terminal sialic acid residue is bound to galactose through an &#x3b1;(2,3) bond; comparing the measured amount thus obtained with a preset cutoff value for prostate carcinoma and benign prostatic hyperplasia, thereby determining that when the measured amount is larger than the cutoff value, prostate carcinoma is developed or the probability of developing prostate carcinoma is high, and when the measured amount is smaller than the cutoff value, benign prostatic hyperplasia is developed or the probability of developing benign prostatic hyperplasia is high.

Method and kit for distinguishing between prostate carcinoma and benign prostatic hyperplasia

A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a &#x3b3;-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Yand Ymean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Yand Yare not the same.) 

Synthetic N-linked sialo-glycan-containing polymer and method for producing the same

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Shizuoka, Japan

Ilpal Jwa