Alkaloida Vegyeszeti Gyar

Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Ilona Bodi

Kalman Hideg

Laszlo Frank

Olga H Hankovszky

Jozsef Csak

Laszlo Jaszlits

Gyorgy Rabloczky

Andras Varro

Marton Fekete

Gyula Horvath

Istvan Elekes

Gyorgy Cseh

Katalin Szemeredi

Peter Matyus

Jozsef Borsi

Geza Szilagyi

Istvan Pallagi

Melinda Gal

Andrea Jednakovits

Erzsebet Zara

Agnes Papp

Eva Bozo

Eva Gal

Gyongyi Nagy Nee Csokas

Endre Tihanyi

Klara Czako

Ildiko Varga

Aniko Miklos Nee Kovacs

Laszlo Czollner

ZSuzanne Lang Nee Rihmer

Luca Levay

Gvorgy Schmidt

Aniko Miklos

Andrea Jednakovics

Antal Simai

Gyorgy Mathe

Adrina Kiss

The invention relates to racemic or optically active 1,3,4-benzotriazepin-5(4H)-one derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said compounds for the treatment of diseases and for the preparation of pharmaceutical compositions containing the said compounds as active agent. The new compounds according to the invention correspond to the general formula (I), ##STR1## wherein R.sup.1 represents hydrogen or straight or branched chain C.sub.1-4 alkyl optionally carrying a pyridyl or a phenyl substituent;

1,3,4-benzotraizepin-5(4H)-one derivatives and process for the

Racemic or optically active new 3(2H)-pyridazinone derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said 3(2H)-pyridazinone derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new 3(2H)-pyridazinone derivatives according to the invention correspond to the general formula (I), ##STR1##

3(2H)-pyridazinone derivatives and process for the preparation thereof

The invention refers to new diamines of the Formula I ##STR1## wherein R stands for ##STR2## or --NH--COA.sup.1 --R.sup.4 or ##STR3## wherein A stands for C.sub.1-5 alkylene which can be substituted by hydroxyl,

Alkyl diamine derivatives

The invention refers to new diamines of the Formula I ##STR1## wherein R stands for ##STR2## wherein A stands for C.sub.1-5 alkylene which can be substituted by hydroxyl,

The invention refers to new diamines of the Formula I ##STR1## wherein stands for ##STR2## wherein A stands for C.sub.1-5 alkylene which can be substituted by hydroxyl,

The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof. The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.

Novel dihydropyridines having calcium antagonistic and antihypertensive

2-(-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl))-amino derivatives

New alkyl diamine derivatives

Growing community of inventors

Tiszavasvari, Hungary

Ilona Bodi