Yonsei University

Ilkoo Noh

Seungjoo Haam

Yong-min Huh

Hyun-Ouk Kim

Jihye Choi

Byunghoon Kang

Eunji Jang

Jaemoon Yang

Jin-Suck Suh

Seung Won Song

Seungmin Han

Seo Ryung Bae

Hwunjae Lee

Haejin Chun

Dayeon Yun

A bioenvironment-sensitive nanoparticle including a polymer having complementary charges, a method of manufacturing the same, and a pharmaceutical use of the bioenvironment-sensitive nanoparticle are disclosed. The bioenvironment-sensitive nanoparticle can be useful in stably and effectively delivering a target material such as a drug even when used at a small quantity since the nanoparticle is stable in extracellular environments. Also, the bioenvironment-sensitive nanoparticle can be useful in selectively diagnosing or treating cancer cells since the nanoparticle is specific to environments of the cancer cells.

Bioenvironment-sensitive nanoparticle comprising polymer having complementary charges

The present invention relates to an amphiphilic nanoparticle specific to a biomarker, and more particularly, provides an amphiphilic nanoparticle which may be used as a diagnosis or treatment-type drug or gene carrier by selectively recognizing a proteolytic enzyme specifically expressed in a cellular membrane of a specific cell, and then being bound to the proteolytic enzyme to efficiently achieve the intracellular uptake and selective cleavage. The amphiphilic nanoparticle of the present invention may be used in the diagnosis or therapy of a disease.

Biomarker specific amphiphilic nanoparticles

The present invention relates to a nanoparticle including a hydrophobic drug conjugated to a cationic polymer and a hydrophilic drug conjugated to an anionic polymer, a method of preparing the same and a pharmaceutical use thereof. The nanoparticle according to an embodiment of the present invention may deliver the hydrophilic drug and the hydrophobic drug at the same time, and may control an initial drug burst. Further, the nanoparticle according to an embodiment of the present invention is specific to a cancer cell environment, and thus selective diagnosis or treatment of cancer cells is possible.

Nanoparticle comprising hydrophobic drug conjugated to cationic polymer and hydrophilic drug conjugated to anionic polymer

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Seoul, South Korea

Ilkoo Noh