Nanoform Finland Oyj

Nanoform Finland Oy

Ilkka Lassila

Jouko Yliruusi

Jenni Pessi

Edward Haeggström

Sami Svanbäck

Heikki Räikkönen

Kai Falck

Antti Meriläinen

Sami Svanback

Heikki Raikkonen

Antti Merilainen

Disclosed are systems and methods for producing particles of organic substances, in particular nanoparticles and microparticles of active pharmaceutical ingredients, wherein the particles are collected in the aid of an extension member engaged to a collection chamber and positioning a nozzle.

System and method to produce particles of organic substances

Disclosed are devices and methods for dissolving sample substances such as drug molecules. Also disclosed is use of the method for device for testing dissolution rates of the sample substances. It utilizes lyophilic matrices that create conditions for discriminating the dissolved sample substance from undissolved sample substances. This is aimed at preventing dispersion of the undissolved sample substance to avoid any substantial membrane effects.

Device, method and kit for dissolution testing

The invention relates to a method and a device for producing nanoparticles of organic substances, in particular by controlled expansion of pressurized solutions. The method comprises: admixing the organic substance and a supercritical fluid to form a mixture at a first pressure; decreasing the first pressure gradually to a second pressure so that a flow of the mixture is formed and nucleation of the organic substance in the mixture is initiated; and, decreasing the second pressure to a third pressure, so that solidification of the fluid of the mixture, comprising the nucleated organic substance, is initiated. The device comprises: a pressure chamber () for a mixture of the organic substance and a supercritical fluid; a collection chamber () for the nanoparticles; an outlet tube () connecting the pressure chamber to the collection chamber (); and, one or more second nozzles (). The outlet tube is provided with a pressure controlling means () configured to control pressure of the mixture within the outlet tube and a first nozzle () configured to allow expansion of the mixture to the collection chamber.

Method and a device for producing nanoparticles

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Helsinki, Finland

Ilkka Lassila