Mesoscale Technologies, Llc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Bioveris Corporation

Ilia V Davydov

John H Kenten

Pankaj Oberoi

Hans Biebuyck

Allan M Weissman

Douglas Woods

Yili Yang

Ka Yin Kwong

Jane P Jensen

Karen H Vousden

Shengyun Fang

Yassamin J Safiran

Nisar Pampori

Steven Yan Cheng

Stefanie Nelson

Stefani Nelson

Ka Y Kwong

The invention provides singleplex and multiplex assays for screening of antigen-binding molecules for their affinity to antigens by normalizing for the concentration of the antigen-binding molecule.

Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule

The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.

Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrate

Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates

The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.

Deazaflavin compounds and methods of use thereof

Apparatus, systems, system components, methods, compositions, and reagents for determining the function and activity of peptides and proteins and for identifying and characterizing molecules that affect these functions and activities. More specifically, methods and reagents used to determine the various activities of peptides and proteins including their binding specificity, binding activity, their enzymatic activity and their ability to act as substrates for enzymes. The disclosed methods are especially suited for the analysis of peptide and protein function where large numbers of peptides and proteins need to be analyzed.

Methods, reagents, kits and apparatus for protein function analysis

Growing community of inventors

Rockville, MD, United States of America

Ilia V Davydov