Qiagen Sciences, LLC

Wave Life Sciences Ltd.

Isoplexis Corporation

Ilia Korboukh

Jerzy Olejnik

Mong Sano Marma

Chandra Vargeese

David Charles Donnell Butler

Pachamuthu Kandasamy

Gopal Reddy Bommineni

Vincent Aduda

Stephany Michelle Standley

Mohammed Rowshon Alam

Snehlata Tripathi

Keith Andrew Bowman

Mamoru Shimizu

Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

Technologies for oligonucleotide preparation

The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3'-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

Methods of using nucleotide analogues

Methods for synthesizing nucleotide analogues with disulfide linkers

Nucleotide analogues

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Needham, MA, United States of America

Ilia Korboukh