The Children's Hospital of Philadelphia

Drexel University

Ilia Fishbein

Robert J Levy

Ivan Alferiev

Michael Chorny

Darryl Williams

Benjamin B Yellen

Boris Polyak

Gennady Friedman

Cunxian Song

Zachary G Forbes

Kenneth A Barbee

A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

Photochemical activation of surfaces for attaching biomaterial

Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

Uniform field magnetization and targeting of therapeutic formulations

A treatment system includes a magnetic targeting catheter and a plurality of MNP. The MNP may include one or more magnetic field-responsive agents and one or more therapeutic agents. The catheter may include an inner shaft having at least one lumen and a fluid delivery balloon adapted to administer a fluid from the inner shaft into a space surrounding the catheter. An expandable mesh formed of a magnetizable material may surround the fluid delivery balloon. The catheter may further include one or more occlusion balloons for controlling blood flow through a vessel in which the catheter is placed. A method of treating a medical condition may include advancing a magnetic targeting catheter to a site, deploying an expandable mesh connected to the catheter, applying a magnetic field to the mesh and depositing a plurality of MNP or cells loaded with MNP near the mesh.

Magnetic targeting device, system and method

A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.

Biodegradable linkers for molecular therapies

A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.

Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex

A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal support, such as a medical device, results in a single molecular layer that can fasten various molecules, thereby minimizing any cellular inflammatory response while enhancing biocompatibility.

Surface modification for improving biocompatibility

A process for preparing the polyurethane derivative, the process including: providing a polyurethane having a urethane amino moiety, providing a multifunctional linker reagent of a formula: LG-R-(FG), wherein n is an integer from 1 to 3, FG is a functional group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, LG is a leaving group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, and Ris an (n+1)-valent organic radical having at least one carbon atom; providing a protected thiol-containing reagent of a formula R&#x2014;C(O)SH, or a salt thereof, wherein R is a Cto Calkyl group; reacting the multifunctional linker reagent with the urethane amino moiety to form a polyurethane substituted with at least one substituent group of a formula: &#x2014;R-(FG); reacting the polyurethane with a protected thiol-containing reagent to form the polyurethane derivative.

Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same

A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane. A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane, wherein the thiol substituent has a formula:&#x2014;R&#x2014;(S&#x2014;R)wherein n is an integer from 1 to 3; Ris an (n+1)-valent organic radical having at least one carbon atom; and Ris a member selected from the group consisting of H, C(O)R, and SR, wherein Ris a member selected from the group consisting of Cto Calkyl and Ris a heterocyclic group or an electron deficient aromatic group.

Growing community of inventors

Philadelphia, PA, United States of America

Ilia Fishbein