Novartis Ag

The Schepens Eye Research Institute, Inc.

Ilene Kay Gipson

Graham M Johnson

John Gerard Steele

Margaret Diana Macrea Evans

Janet Helen Fitton

Beatrice Ann Dalton

A corneal onlay or corneal implant is disclosed which is to be placed within or onto the surface of the cornea, being a biocompatible, optically transparent, synthetic and biostable polymeric material, said material comprising a surface that supports the attachment and growth of tissue cells, and where the exterior surface of the implant onto which epithelial tissue is to be attracted and to become attached, or in the case of a corneal onlay the anterior surface of the onlay, has a topography comprising a plurality of surface indentations.

Corneal onlay

A monoclonal antibody has been produced that binds to apical cells of human ocular surface and vaginal epithelia. The antigen recognized by this monoclonal antibody is a mucin-like cell surface glycoprotein. The antibody is of diagnostic use in the evaluation of the ocular surface in dry eye patients, and the antigen has therapeutic potential for use in treatment of dry eye disease. In a comparison of dry eye and normal patients the pattern of antibody binding to dry eye ocular surface epithelia has been shown to differ from the binding pattern seen in normal epithelia.

Antibody to ocular and vaginal surface epithelium

Growing community of inventors

Concord, MA, United States of America

Ilene Kay Gipson