Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Ildiko Wuensche

Christian Klein

Pablo Umana

Guy Georges

Stefan Seeber

Joerg Thomas Regula

Georg Fertig

Tilman Schlothauer

Jens Fischer

Joerg Benz

Valeria Lifke

Viktor Levitski

Barbara Weiser

Laura Codarri Deak

Mario Perro

Adrian Zwick

Victor Levitsky

Laura Codarri-Deak

Sebastian Fenn

Stefan Dengl

Oliver Ploettner

The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to 5 TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.

Bispecific antibodies specific for PD1 and TIM3

The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.

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Penzberg, Germany

Ildiko Wuensche