Basf Aktiengesellschaft

Fujimoto Co., Ltd.

Semmelweis University

Ildikó Miklya

Lujza E Petocz

Jozsef Knoll

Marton Fekete

Attila Mandi

Istvan Gyertyan

Istvan Gacsalyi

Berta Knoll

Péter Ferdinandy

Zsuzsanna Schaff

Sándor Eckhardt

József Knoll

Dezso Schuler

Gabriella Zsilla

Edit Berenyi Nee Poldermann

Katalin Budai Nee Simonyi

Edit Berenyi Ne Poldermann

Ne Simonyi Budai

The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field. A novel tumor manifestation suppression (TMS) regulation in a mammalian brain is recognized. The invention relates to compounds, pharmaceutical preparations, in particular medicaments for use in the prevention and treatment of cancer, in particular suppression of tumor manifestation based on said TMS regulation as well as methods for the same.

Compounds for use in the prevention or treatment of cancer

The 3-amino-4-ethylthio-quinoline of the Formula I ##STR1## and pharmaceutically acceptable acid addition salts thereof possess useful therapeutical properties. They exhibit a potent and highly selective anxiolytic and narcosis potentiating effect and are devoid of sedative and anti-convulsive effect. Consequently, the invention relates to pharmaceutical compositions comprising the compound of Formula I or a salt thereof as active agent. The invention also relates to a new and improved process for the preparation of the compound of Formula I.

Pharmaceutical compositions

The new compounds of the general Formula I ##STR1## (wherein R.sub.1 stands for C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.2-5 alkinyl, C.sub.3-7 cycloalkyl or optionally substituted phenyl-(C.sub.1-4 alkyl);

Quinoline thioethers

Growing community of inventors

Budapest, Hungary

Ildikó Miklya