Institute for Drug Research Ltd.

Biogal Gyogyszergyar Rt.

Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Ildiko Lang

Istvan M Szabo

Istvan Barta

Karoly Albrecht

Julianna Mozes Nee Suto

Gyula Horvath

Gabor Ambrus

Attila Andor

Janos Erdei

Valeria Szell

Eva Ilkoy

Antonia Jekkel

Gyorgy Somogyi

Eva Gulyas

Margit Bidlo Nee Igloy

Gabor Balogh

Sandor Boros

Janso Salat

Magdolna Petroczki

Attila Konya

Aniko Tedges

Laszlo Birincsik

Laszlo Birinesik

Janos Salat

A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of abacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of thesp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20&#xb0; C. and 30&#xb0; C. containing organic nitrogen and carbon sources and, optionally, mineral salts.

Process for the preparation of pseudomonic acid a antibiotic by microbiological method

Microbial process for preparing pravastatin

A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20&deg; C. and 30&deg; C. containing organic nitrogen and carbon sources and, optionally, mineral salts.

Process for the preparation of pseudomonic acid A antibiotic by microbiological method

Growing community of inventors

Budapest, Hungary

Ildiko Lang