Richter Gedeon Vegyeszeti Gyar Rt

Ildiko Kiraly

Erzsebet Mago Nee Karacsony

Laszlo Tardos

Jozsef Borsi

Sandor Bajusz

Istvan Elekes

Lajos Toldy

Sandor Elek

Istvan Polgari

Endre Csanyi

Jozsef Borsy

Andras Ronay

The invention relates to new ergol-8-ene and ergoline derivatives of the general formula /I/ ##STR1## wherein x y stands for --CH.dbd.C.dbd. or --CH.sub.2 --CH.dbd. group,

Novel ergol-8-ene and ergolin compounds and process for preparing same

The invention relates to a novel compound of the formula ##STR1## and the pharmaceuticlly acceptable acid addition salts thereof, wherein R stands for a hydrogen atom or methyl group, x y designates a ##STR2## Q is a hydrogen atom or a benzyloxycarbonyl- or N-tert.-butyloxycarbonyl protective group, and R.sub.1 is the side chain of a natural .alpha.-amino acid selected from the group consisting of Arg--, Tryp-13 , Phe--, Ser--, Leu--, Val--, Meth--, Tyr--, His-- or Prol---side-chain. The compounds according to the invention possess antiserotonin and hypotensive effects and act upon the central nervous system.

Compounds of ergolene and ergoline structure and method for the

9,10-Dihydrolysergic acid-(3'-/pyrrolid-2'-on-1'-yl/-propyl)-amide, 1-methyl-9,10-dihydrolysergic acid-(thiazoline-2'-yl)-amide and lysergic acid-(3'-allyloxy-2'-oxy-propyl)-amide and their pharmaceutically acceptable acid addition salts possess antihypertensive and antiserotonin effect and exert an action on the central nervous system.

Novel lysergic acid amides and process for preparing same

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Budapest, Hungary

Ildiko Kiraly