Zach System S.p.a.

F.i.s. Fabbrica Italiana Sintetici S.p.a.

Ilaria Munari

Livius Cotarca

Massimo Verzini

Raffaella Volpicelli

Franco Massaccesi

Paolo Maragni

Johnny Foletto

Roberto Brescello

Ivan Michieletto

Mauro Andretto

Elisa Melotto

Anna Smaniotto

Antonio Nardi

Vincenzo Frega

The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I). 

Process for preparing enantiomerically enriched oxamides

The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.

Process for preparing a ketosulfone derivative

The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (&#x2212;)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol. 

Process for preparing nebivolol

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Vicenza, Italy

Ilaria Munari