Nvision Imaging Technologies Gmbh

Universitat Ulm

Other

Ilai Schwartz

Martin Bodo Plenio

Stephan Knecht

Michael Keim

Qiong Chen

Tobias Schaub

Matthias Pfender

Philipp Neumann

Fedor Jelezko

Alex Retzker

Jianming Cai

Tim Eichhorn

John Blanchard

Anna Parker

Benedikt Tratzmiller

Boris Naydenov

Zhenyu Wang

Joachim Rosskopf

Liam McGuinness

Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

Systems and methods for generation of hyperpolarized materials

The present disclosure describes non-classical (e.g., quantum) computing systems and methods that utilize dopant molecules contained in host materials as qubits.

Systems and methods for quantum computing

Systems and methods are disclosed for increasing a nuclear spin polarization in a target compound. Nuclear spin polarization can be increased by obtaining the target compound or a precursor of the target compound. The target compound or precursor can include a first proton and a second proton sharing a singlet spin order and a third proton coupled at least to one of the first proton or the second proton. A target atom can be coupled to at least the third proton. The precursor can be placed within a mean magnetic field strength below 500 mT. A magnetic resonance (MR) pulse sequence can be applied to the precursor. the MR pulse sequence configured to transfer population from the first and second protons to the target atom, thereby imparting a non-equilibrium nuclear spin polarization of at least 1%, 2%, 5%, 10%, or 20% to the target atom.

Systems and methods for generation of hyperpolarized compounds using parahydrogen

The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

Systems and method for generation of hyperpolarized materials

Systems and method for quantum computing

A method for generating a nuclear magnetic resonance spectrum of nuclear spin moments of a sample includes a static magnetic field permeating the sample, and a detection spin moment with a detection region surrounding the latter. The detection region extends at least partly into the sample. The method also includes an antenna element for radiating in frequency pulses for influencing the nuclear spin moments and radio-frequency pulses for influencing the detection spin moment, where a polarization step involves polarizing at least one portion of the nuclear spin moments along the magnetic field to form a longitudinal magnetization, where a transfer step involves converting the longitudinal magnetization (M) into a transverse magnetization (M) by radiating in a frequency pulse (F) with a 90&#xb0; flip angle, wherein a detection step involves radiating in a sequence of radio-frequency pulses onto the detection spin moment and subsequently detecting a signal (') of the transverse magnetization (M) present in the detection region and storing the signal as detection result in a list. The detection step is carried out a number of times repeatedly in succession, wherein the polarization step and the transfer step and also the detection steps are carried out.

Method and device for generating a nuclear magnetic resonance spectrum of nuclear spin moments of a sample

The invention relates to a method for the hyperpolarization of a material sample (), which hits a number of first spin moments () of a first spin moment type, wherein the number of first spin moments () is brought into interaction with a second spin moment () of a second spin moment type, wherein the first spin moments () are nuclear spin moments and the second spin moment () is an election spin moment, wherein the first and second spin moments () are exposed to a homogeneous magnetic field (B), wherein the second spin moment () is polarized along the magnetic field (B), wherein the second spin moment () is coherently manipulated by means of a, preferably repeated, sequence (S) having a number of successive high-frequency pulses (P, P) temporally offset to each by durations (T, T, T), in such a way that a polarization transfer from the second spin moment () to the first spin moments () occurs, and wherein durations (T, T, T) inversely proportional to a Lamor frequency (&#x3c9;) of the first spin moments () in the magnetic field (B) are inserted between high-frequency pulses (P, P).

Method and device for the hyperpolarization of a material sample

A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.

Growing community of inventors

Neu-Ulm, Germany

Ilai Schwartz