Mitsubishi Tanabe Pharma Corporation

Tanabe Seiyaku Company, Limited

Ila Sircar

Takayuki Kawaguchi

Toshiyuki Kume

Sumihiro Nomura

Mikiko Tsukimoto

Nicholas D Smith

Marshall Morningstar

Paul Furth

Richard Martin

Bradley Teegarden

Ronald Griffith

Kristjan S Gudmundsson

Masatoshi Kakushima

Yun Feng Xie

Hidefumi Kaji

The present invention relates to a phenylalanine derivative of Formula (I) wherein Xis a halogen atom, Xis a halogen atom, Q is a CHR&#x2014; is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.

[object Object]

Inhibitors of alpha4 mediated cell adhesion

The present invention relates to a compound of formula (I): wherein R is hydrogen atom, hydroxyl group or carbamoyl group, and n is 1 or 2, or a pharmaceutically acceptable salt thereof. 

The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating &#x3b1;&#x3b2;adhesion mediated conditions in a mammal.

The present invention relates to a compound of the following formula:or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating &#x3b1;&#x3b2;adhesion mediated conditions in a mammal.

Inhibitors of &#x3b1;L&#x3b2;2 mediated cell adhesion

The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, &#x2014;O&#x2014; -(lower alkylene)-, etc.; n is 0, 1 or 2; Z is oxygen or sulfur; W is oxygen, sulfur, &#x2014;CH&#x2550;CH&#x2014;, &#x2014;NH&#x2014; or &#x2014;N&#x2550;CH&#x2014;; R, Rand Rare the same or different and are hydrogen, halogen, hydroxyl, a substituted or unsubstituted lower alkyl gorup, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, etc.; Ris tetrazolyl, carboxyl group, amide or ester; Ris hydrogen, nitro, amino, hydroxyl, lower alkanoyl, lower alkyl, etc.; Ris selected from (a) a substituted or unsubstituted phenyl group, (b) a substituted or unsubstituted pyridyl group, (c) a substituted or unsubstituted thienyl group, (d) a substituted or unsubstituted benzofuranyl group, etc.; or a pharmaceutically acceptable salt thereof.

Inhibitors of &#x3b1;4 mediated cell adhesion

The present invention relates to small molecules according to formula (I) that are potent inhibitors of &agr; &bgr; mediated cell adhesion and which could be useful for the treatment of inflammatory diseases:

Growing community of inventors

San Diego, CA, United States of America

Ila Sircar