Johns Hopkins University

Chinese Academy of Sciences

Il Minn

Martin Gilbert Pomper

Ronnie Charles Mease

Shawn Lupold

Mark Castanares

Hai-Quan Mao

Jun O Liu

Sangeeta Ray

Xing Yang

Jordan J Green

Steven M Rowe

Biao Yu

Jose Luis Santos

Haofan Wang

Yong Ren

Mohamad Allaf

Qingli He

Qiaoling Wang

Michael Gorin

Steven D Leach

Maani Archang

John Michael Williford

Hannah Vaughan

Camila Gadens Zamboni

Steven Rowe

Martin G Pomper

Ronnie C Mease

Methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues are provided.

PSMA-based molecular-genetic reporter system

A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.

Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy

Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (PEG) polymer having an average molecular weight less than 1 kDa, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.

Compositions of nucleic acid-containing nanoparticles for in vivo delivery

The presently disclosed subject matter provides methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues.

Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.

Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX and uses thereof

Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

Glucose conjugates of triptolide, analogs and uses thereof

A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.

Red fluorescent aldehyde dehydrogenase (ALDH) substrate

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Ellicott City, MD, United States of America

Il Minn