Cj Corporation

Cj Cheiljedang Corporation

Cheiljedang Corp.

Cheil Foods & Chemicals, Inc.

Il Hwan Cho

Jong Hoon Kim

Ji Young Noh

Hyung Chul Ryu

Sang Wook Park

Sung Hak Jung

Myeong Yun Chae

Hyun Jung Park

Jee Woong Lim

Young Hoon Kim

Kyu Jeong Yeon

Young Mee Chung

Hyung Ok Chun

Yong Sik Youn

Dong Hyun Ko

Kyoung Rae Kang

In Ki Min

Jie Eun Park

Sung Hak Lee

Je Hak Kim

So Young Wang

Sang Jin Park

Young Jun Shin

Dong Kwon Lim

Choong S Kim

Ki Hoon Lee

Hae Tak Jin

Jae Mok Lee

Jin Woong Kim

Je Kyoung Kim

Seung Ho An

Dal Hyun Kim

Taerho Kim

Chun Seon Lyu

Seog Beom Song

Yong Hwan Jung

Il Hwan Kim

Eun Young Lee

Kwang Do Choi

Min Kyoung Lee

Myeong Sik Yoon

Yong Tack Lee

Si Beum Lee

Da Won Oh

Seong Cheol Bang

Hye Suk Hong

The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50&#xb0; C. under the presence of dimethylsulfoxide and triethylamine solvents. 

Production method for adefovir dipivoxil

Disclosed is a method for the separation of S-(&#x2212;)-amlodipine from a racemic amlodipine. Featuring the use of inexpensive L-tartaric acid as an optical resolution agent and DMAC as a solvent, the separation method allows the resolution of S-(&#x2212;)-amlodipine from racemic amlodipine at high yield and to a satisfactory enantiomeric excess and thus is economically favorable and applicable to the mass production of the optical isomer.

Method for the separation of S-(&#x2212;)-amlodipine from racemic amlodipine

Disclosed are crystalline S-(&#x2212;)-amlodipine adipic acid salt anhydrous and a preparation method thereof. The crystalline S-(&#x2212;)-amlodipine adipic acid salt anhydrous exhibits excellent physical and chemical properties including non-hygroscopicity, solubility, thermal stability, and photostability, and is superior in formulation processability and long-term storage safety.

Crystalline S-(&#x2212;)-amlodipine adipic acid salt anhydrous and preparation method thereof

A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

Thione derivative, method for the preparation thereof, and pharmaceutical composition containing the same

1,2,4-triazole derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same

A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided:  wherein: Rrepresents naphthyl, indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzothiazolyl, benzotriazolyl, benzooxazolyl, quinolinyl, or isoquinolinyl; wherein, Ris optionally substituted at a substitutable position with one or more radicals independently selected from halogen, hydroxy, nitro, C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Chaloalkoxy, cyano, amino, monoalkylamino, and dialkylamino; Rrepresents methyl or amino; and A, B, E, and D each independently represent carbon or nitrogen.

1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same

A 1,2,4-Triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

1,2,4-Triazole derivative, method for preparing the same, and pharmaceutical composition containing the same

The present invention relates to an isothiazole derivative of the following formula 1 or nontoxic salt thereof: According to the present invention, isothiazole derivative or nontoxic salt thereof having antipyretic, analgesic and antiphlogistic activity and an improved side effect; process for the preparation thereof; and pharmaceutical composition including the same can be provided.

Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same

A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided:

Thiazolidine-4-one derivative, method for preparing the same, and pharmaceutical composition containing the same

2-thioxothiazole derivative, method for preparing the same, and pharmaceutical composition containing the same

Pyrazole-3-one derivative, method for preparing the same, and pharmaceutical composition containing the same

3,4-dihydro-1H-naphthalene derivatives as a highly selective cyclooxygenase-2 inhibitor

1H-indole derivatives as a highly selective cyclooxygenase-2 inhibitor

4&prime;-methanesulfonyl-biphenyl derivatives as a highly selective cyclooxygenase-2 inhibitor

Growing community of inventors

Seoul, South Korea

Il Hwan Cho