Korea Institute of Ocean Science & Technology

Il-Chan Kim

Joung Han Yim

Se Jong Han

Ha Ju Park

Jun Hyuck Lee

Tai Kyoung Kim

Dong-Gyu Jo

Chul Soo Shin

Dockyu Kim

Hong Kum Lee

Bon-Hun Koo

Ui Joung Youn

Min Ju Kim

Sung Jin Kim

Pil-Sung Kang

Jung Eun Kim

Ju Mi Hong

Jin Haeng Song

Kwon Joo Yeo

The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichenand selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.

Method for synthesis of lobaric acid and analog thereof

The present invention relates to an exopolysaccharide derived fromsp. strain CY01 (KCTC 12867BP) which is a novel strain living in the polar regions, and to a composition for cryoprotection of cells, which contains the exopolysaccharide. The exopolysaccharide of the present invention has an excellent ability to cryoprotect cells, and shows no cytotoxicity. Thus, the inventive exopolysaccharide can substitute for conventional cryoprotective agents that show cytotoxicity when used at high concentrations.

Cryoprotective agent containing exopolysaccharide fromsp. CY01

The present invention relates to a neurodegenerative disease treatment use, which is a novel use of Ramalin, and, more specifically, to a composition for preventing or treating neurodegenerative diseases, containing Ramalin, which has an inflammasome and BACE1 expression inhibitory activity. Ramalin according to the present invention has an effect of improving a cognitive ability by inhibiting the expression of an inflammatory factor, which contains an NLRP inflammasome protein, and BACE1, and is thus useful for preventing or treating memory disorder and neurodegenerative diseases.

Composition for preventing or treating neurodegenerative diseases, containing Ramalin

A cold-adapted protease derived fromPAMC 21717 or a recombinant cold-adapted protease obtained by expressing a gene encoding the cold-adapted protease inis described, and more particularly, a crystal of a protease exhibiting activity at low temperatures, a method for crystallizing the protease, a method for preparing the protease, a recombinant microorganism that expresses the protease, a method for preparing the recombinant microorganism, a method for preparing the recombinant protease and the use of the cold-adapted protease. The cold-adapted protease exhibits high activity at low temperatures, and securely maintains its enzymatic activity even in the presence of high pH, various metal ions and surfactants. Thus, it is useful in various industrial applications.

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Growing community of inventors

Gyeonggi-do, South Korea

Il-Chan Kim