Mitsui Petrochemical Industries, Ltd.

Mitsui Pharmaceuticals, Inc.

Mitsui Chemicals, Inc.

Ikuo Tomino

Akira Awaya

Noriaki Kihara

Kazutoshi Horikomi

Akira Mizuchi

Tadayuki Sasaki

Takumi Kitahara

Keiichi Yokoyama

Takuo Nakano

Mitsuyuki Takesue

Takafumi Ishihara

Hiroaki Tan

Hisashi Kobayashi

Masaharu Ishiguro

Teruaki Mukaiyama

Isao Hashimoto

Ken Ikeda

Joji Kamiya

Hiroyasu Ohno

Yasuhiro Hara

Masaaki Ishii

Shintaro Araki

Yukihito Yukimune

Koji Kato

Shigeru Isayama

Kanji Yoshihara

Kozi Kato

Yuichiro Kokubun

Kojun Torigoe

Ken E Tan

Fumiaki Ito

Houji Kato

The present invention relates to a method of producing a taxane-type diterpene wherein a cell and/or a tissue of a plant which produces the taxane-type diterpene is cultured in the presence of at least one substance selected from the group consisting of coronatines, a bacterium which produces the coronatines, a culture solution or a culture extract of such bacterium, cyclic polysaccharides, fatty acids, and an imino or amino derivative of jasmonic acids, then the taxane-type diterpene is recovered from the resulting cultures.

Method of producing a taxane-type diterpene

The present invention provides a method for the screening of a wound-healing agent, which comprises determining a substance to be active as a wound-healing agent on the basis of potentiation or modification of biological activities of a growth and/or differentiation factor, a growth hormone or a cytokine. This invention also provides a wound-healing method, which comprises as an active ingredient a compound of the following formula (1) or formula (2) found to be active by the screening method. ##STR1##

Method for healing compromised tissues using pyrimidine derivatives

Pyrimidine compound and pharmaceutically acceptable salts thereof

This invention provides novel pyrimidines or their pharmaceutically acceptable salts thereof and process for preparation thereof. The novel compounds are useful for neurological diseases of the peripheral and central nervous systems of animals.

Pyrimidines and pharmaceutically acceptable salts thereof useful in

2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological deseases.

Pyrimidines and their pharmaceutical acceptable salts, and their use as

Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for the treatment and prevention of heart diseases of animals, particularly arrhythima, myocardial infarction, angina pectoris and heart failure and psychoneurological diseases.

Coumaran group containing amine compounds and their acid addition salts

2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological diseases.

2,6-di,2,4,6-, 2,5,6-tri and 2,4,5,6-tetra-substituted pyrimidines,

A novel N-substituted imidazole or thioimidazole derivative and a pharmacologically acceptable acid addition salt thereof, which have a brain function-improving action, are disclosed. The derivative or salt is used as an effective ingredient of a brain function-improving medicine.

Imidazole derivatives having anti-hypoxia properties

A novel nitrogen-containing compound capable of preventing hardening of blood vessels by controlling formation of peroxide lipids in cell membranes, which is valuable as an anti-arteriosclerotic agent, is disclosed.

Nitrogen-containing compound

Therapeutic agent for neurological diseases

N-cyano-N'-methyl-N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidine (Cimetidine), which is valuable as an agent for controlling secretion of gastric acid, is prepared in a high yield by reacting N-cyano-N'-methyl-N'-(2-(butane-2,3-dionyl)thioethyl)-guanidine as the starting compound with an ammonium salt of a carboxylic acid and formaldehyde.

Process for preparation of guanidine derivative

Growing community of inventors

Ohtake, Japan

Ikuo Tomino