Nec Solution Innovators, Ltd.

Gunma University

Ikuo Shiratori

Iwao Waga

Katsunori Horii

Jou Akitomi

Naoto Kaneko

Hirotaka Minagawa

Masayasu Kuwahara

Yoshihito Yoshida

Tomoko Shiratori

Hiroshi Mishima

Tomoko Murata

The present invention provides a novel nucleic acid molecule that can be used for detection of a wheat allergen. The wheat allergen-binding nucleic acid according to the present invention is characterized in that it binds to a wheat allergen with a dissociation constant of 20 nM or less, and preferably includes a polynucleotide consisting of either of base sequences of SEQ ID NOs: 1 and 2, for example.

Wheat allergen-binding nucleic acid molecule and use thereof

The present invention provides a novel fluorescent protein. A novel protein includes the following protein (F1):

Protein, novel gene, expression vector, transformant, method for producing transformant, and method for screening for novel fluorescent protein

The present invention provides a novel nucleic acid molecule that can be used for detection of &#x3b1;-amylase. The &#x3b1;-amylase-binding nucleic acid molecule of the present invention is characterized in that it binds to &#x3b1;-amylase with a dissociation constant of 17 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 22, for example. According to the nucleic acid molecule of the present invention, it is possible to detect &#x3b1;-amylase in saliva.

&#x3b1;-amylase-binding nucleic acid molecule and use thereof

The present invention is intended to provide a novel fluorescence sensor for target analysis, a kit for target analysis, and a target analysis method using the same. The fluorescence sensor for target analysis according to the present invention includes a nucleic acid molecule that includes a G-quartet-forming nucleic acid region (D) that forms a G-quartet and a binding nucleic acid region (A) that binds to a target. In the absence of a target, formation of a G-quartet in the G-quartet-forming nucleic acid region (D) is inhibited. In the presence of a target, the target comes into contact with the binding nucleic acid region (A), the G-quartet is formed in the G-quartet-forming nucleic acid region (D) due to the contact, the G-quartet-forming region (D) and porphyrin forms a complex, and the complex generates fluorescence.

Fluorescence sensor for target analysis, kit for target analysis, and target analysis method using same

The present invention provides a novel nucleic acid molecule that can be used for detection of peanuts. The peanut-binding nucleic acid molecule of the present invention is characterized in that it binds to a peanut allergen with a dissociation constant of 10 nM or less, and preferably contains a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 15, for example. It is also preferable that, for example, the peanut-binding nucleic acid molecule of the present invention binds with significant specificity to the peanut allergen rather than to a soybean protein.

Growing community of inventors

Tokyo, Japan

Ikuo Shiratori