Fuji Photo Film Company, Limited

Takara Shuzo Co., Inc.

Ikuo Saiki

Ichiro Azuma

Naoyuki Nishikawa

Masayoshi Kojima

Hiroyuki Komazawa

Atsushi Orikasa

Ikunoshin Kato

Mitsunori Ono

Hideto Mori

Hiroshi Kitaguchi

Fusao Kimizuka

Hideaki Satoh

Yoh'ichi Ohdate

Yuki Taguchi

Shouichi Goto

Yasutoshi Kawase

There are disclosed amino acid derivatives represented by the following general formula (I): ##STR1## wherein L.sup.1 and L.sup.2 represent an amino acid residue etc., A.sup.1 and A.sup.3 represent C.dbd.O, A.sup.2 represents an alkylene group etc., m and n represent an integer of 1 to 5, V represents --NHC(.dbd.NH)NH.sub.2 etc., W represents --COOH etc., R.sup.1 and R.sup.2 represent hydrogen atom, alkyl group etc., R.sup.3 and R.sup.4 represent hydrogen etc. and X and Y represent --NH-- or --O-- and pharmaceutically acceptable salts thereof and agents for inhibiting tumor matastasis containing the compounds, and the amino acid derivatives exhibit high activity for inhibiting tumor metastasis and weak platelet aggregation inhibition activity and weak anticoagulation activity.

Amino acid derivatives and application thereof

A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;

Tumor metastasis inhibiting compounds and methods

This invention relates to a functional polypeptide containing the binding domain of human fibronectin and the heparin-binding domain of human fibronectin.

Functional polypeptide containing a cell binding domain and a heparin

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Sapporo, Japan

Ikuo Saiki