Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Kyowa Hakko Kogyo K.k.

Ikuo Matsukuma

Tadashi Hirata

Yukio Hashimoto

Shigeo Yoshiie

Takehiro Ogasa

Masayuki Teranishi

Seigo Takasawa

Shigeru Kobayashi

Kazuo Kimura

Makoto Morimoto

Katsuichi Shuto

Nobuhiro Nakamizo

Yasushi Shida

Chikara Murakata

Shiro Akinaga

Tadashi Ashizawa

Koji Yamada

Shunji Ichikawa

Tokuyuki Kuroda

Kiyoshi Sato

Yukiteru Mimura

Toru Sugaya

Yutaka Osawa

Teruyuki Tsuruta

Masanobu Kawai

Yoichi Ohashi

Novel pyrazoloacridone compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have an excellent anti-tumor activity.

6H-pyrazolo-[4,5,1-d,e]acridin-6-one derivatives having anit-tumor

Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.

Mitomycin compounds having useful anti-tumor activity

Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.

Optically active carbacephems

Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.

Optically active 3-halo carbacephems

Novel cephalosporin analogs are disclosed which have antibacterial activity. Methods for producing the compounds are also disclosed.

3-position halogenated cephalosporin analogs and pharmaceutical

Offered is an anticonvulsive composition which comprises an effective amount of a dihydrouracil derivative represented by the formula: ##STR1## [wherein one of A and B is ##STR2## (wherein Y.sub.1, Y.sub.2 and Y.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms, nitro groups, amino groups, carboxyl groups, lower alkoxycarbonyl groups or trifluoromethyl groups), a naphthyl group or a diphenylmethyl group, and the other is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a cyclopentyl group, a cyclohexyl group or ##STR3## (wherein Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms or trifluoromethyl groups), R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms or lower alkyl groups, and X is an oxygen atom or a sulfur atom] and at least one pharmaceutically acceptable carrier.

Treating convulsions with dihydrouracil derivatives

Process for producing optically active cephalosporin analogs

Optically active cephalosporin analogs are produced by an optically selective acylation reaction. The reaction is carried out in the presence of a microbial enzyme which catalyzes the selective optical acylation. The products thus obtained are useful as antibacterial agents.

Process for producing cephalosporin analogs

Process of producing optically active cephalosporin analogs by enzyme

Novel compounds are disclosed which are useful as agents capable, when applied to citrus tree, of modifying the metabolism and organic acid content of the citrus fruit.

Agents for and method of modifying citrus fruit

This invention relates to certain derivatives of phenylalanine having interesting pharmaceutical properties, in particular, a lipid-lowering activity.

Phenylalanine derivatives

Growing community of inventors

Yokkaichi, Japan

Ikuo Matsukuma