Eisai Company, Limited

Ikuo Kushida

Kazuhide Ashizawa

Yasuyuki Suzuki

Masahiko Tsujii

Hiroyuki Chiba

Taiju Nakamura

Akio Kayano

Tomohiro Watanabe

Kazuhiro Kaneko

Yasuyuki Asai

Shin Sakurai

Hiroyuki Ishizuka

Hiroyuki Saito

Takako Yoshiba

Masahiro Sakurai

Eiichi Yamamoto

Astsushi Koiwa

Yoshihisa Sano

Kiyomi Kikuchi

The present invention provides carbapenem hydrochloride trihydrate crystals, which are chemically stable, easily purified and useful as antimicrobial agents, a process for producing them, and a powdery charged preparation for injection containing them. That is, it provides carbapenem hydrochloride trihydrate crystals having a powdery X-ray diffraction pattern containing lattice distances (d) of 9.0, 4.1 and 2.8 &#x212b;, a process for producing them, and a powdery charged preparation for injection containing them.

Carbapenem compound crystals and interjection preparations

The present invention provides an evaluation method and preparation process of injection containing a lipid A analog. Specifically, it provides, in an injection preparation containing a lipid A analog or a pharmacologically acceptable salt thereof, forecasting and evaluating methods of the pharmacokinetics of the lipid A analog, and quality evaluating method and preparation process of the injection, which each comprises measuring membrane fluidity and/or circular dichroism.

Method for evaluating lipid a analog-containing injections

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Ibaraki, Japan

Ikuo Kushida