Lederle (Japan), Ltd.

Nisshin Flour Milling Co., Ltd.

Nitto-Denko Corporation

Ikuo Kishi

Yoshiyuki Tahara

Masanori Sugita

Osamu Ogawa

Hideo Yoshida

Mitsuhiko Hori

Shoichi Tokuda

Masaki Sunami

Koji Maruyama

Kenichiro Saito

A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.

Preparation for transdermal drug administration

A pharmaceutical oil-in-water type microemulsion having an action of potentiating the activities of anti-cancer agents, said micro-emulsion comprises

Anti-cancer activity potentiator

A pharmaceutical oil-in-water type microemulsion having an action of potentiating the activities of anti-cancer agents, said micro-emulsion comprises fine particles of a vegetable oil or a triglyceride of a medium-chain fatty acid having 8 to 12 carbon atoms containing 0.1 to 10% (w/v) of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine malate of formula (I) below, ##STR1## an aqueous medium, and, 0.05 to 25% (w/v) of a physiologically acceptable phospholipid for dispersing said fine particles in said aqueous medium.

An antiinflammatory analgesic gelled ointment comprising a phenylacetic acid type antiinflammatory analgesic agent, a carboxyvinyl polymer in an amount sufficient for gel formation, a water-soluble organic amine, a lower alcohol and water and having a pH in the range of from 7.0 to 9.0.

Antiinflammatory analgesic gelled ointments

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Ichikawa, Japan

Ikuo Kishi