Fujisawa Pharmaceutical Company, Ltd.

Anges Mg, Inc.

Ikuo Kawamura

Ryuichi Morishita

Toshiyuki Chiba

Kazuhiro Maeda

Toshio Ogiwara

Toshiko Sugimoto

Mariko Ohta

Shigeru Takeshita

Administration of a decoy, i.e. a compound which specifically antagonizes the nucleic acid domain to which NF-&#x3ba;B is bound, is effective in the treatment and prevention of diseases caused by the transcriptional regulatory factor NF-&#x3ba;B, such as ischemic diseases, inflammatory diseases, autoimmune diseases, cancer metastasis and invasion, and cachexia.

Remedy and preventive for diseases caused by NF-&#x3ba;B

The invention provides a composition for improving an action of an immunosuppressant, comprising insulin-like growth factor I or its analog as an active ingredient.

Immunosuppressant activity of insulin-like growth factor I (IGF-I)

Administration of a decoy, i.e. a compound which specifically antagonizes the nucleic acid domain to which NF-&kgr;B is bound, is effective in the treatment and prevention of diseases caused by the transcriptional regulatory factor NF-&kgr;B, such as ischemic diseases, inflammatory diseases, autoimmune diseases, cancer metastasis and invasion, and cachexia.

Remedy for diseases associated with NF-&kgr;B

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Hirakata, Japan

Ikuo Kawamura