Kabushiki Kaisha Yakult Honsha

Taiyo Yuden Kabushiki Kaisha

Terumo Kabushiki Kaisha

Ikuo Kato

Yasuo Kurosaki

Kenichiro Nogi

Seigo Sawada

Masahiko Mutai

Shigenori Nozawa

Masashi Isozaki

Teruo Yokokura

Takeshi Matsuzaki

Keisuke Yoshino

Seizaburo Kobayashi

Yoshitaka Ogata

Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.

Irinotecan preparation

Electronic parts, such as an inductor, of improved connectivity between magnetic and conductive materials are made by sintering magnetic material under a condition in which no accumulation is developed, by forming a hollow-core of a shape different from an external shape of said conductive material through said magnetic material to be molded by an extrusion-molding means while inserting said magnetic material into said hollow-core, or by providing an erasable means to be removed by a heat treatment in said conductive material and conducting extrusion molding so as to embed said conductive material into said magnetic material, said erasable means being removed during a sintering treatment to form a space between said conductive material and said magnetic material, and a method for making same.

Method for making electronic parts

Electronic parts such as an inductor of improved connectivity between magnetic and conductive materials made by sintering the magnetic material under a condition where no accumulation is developed, by forming a hollow-core of a shape different from an external shape of said conductive material through said magnetic material to be molded by an extrusion-molding means while inserting said magnetic material into said hollow-core, or by providing an erasable means to be removed by a heat treatment in said conductive material and conducting extrusion molding so as to embed said conductive material into said magnetic material, said erasable means being removed during a sintering treatment to form a space between said conductive material and said magnetic material, and a method for making same.

Electronic parts such as an inductor and method for making same

Immunostimulating agent for inhibiting tumors comprising Lactobacillus casei YIT 9018 and methods for treating and/or preventing tumor growth.

Antitumor agent containing Lactobacillus casei YIT 9018

Growing community of inventors

Tokyo, Japan

Ikuo Kato