Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Boehringer Ingelheim Kg

Nippon Chemiphar Co., Ltd.

Pharmacome LLC

Ikunobu Muramatsu

Franz Esser

Hisato Kitagawa

Pascale Pouzet

Sven Luettke

Shuji Uchida

Helmut Staehle

Naoki Ishiguro

Kenji Sakai

A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPCR are screened using a transformant in which the modified GPCR has been expressed. This makes it possible to provide a technique for analyzing the function of many putative GPCRs whose entities have not been clarified.

Methods of using an alpha-1-adrenergic receptor having altered ligand affinity

Compounds of the formula (II)wherein R, R, R, R, and Rare as set forth herein, pharmaceutical compositions containing them, and their use in treating urinary incontinence.

Compounds and methods for treating urinary incontinence

The present invention relates to the use of &#x3b1;-agonists for treating urinary incontinence.

m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence

The present invention relates to 2&prime;-halo-3&prime;,5&prime;-dialkoxyphen-1&prime;-yl-imino-2-imidazolidine, the tautomeric 2&prime;-halo-3&prime;,5&prime;-dialkoxyanilino-2-imidazoline and/or the pharmacologically acceptable salts thereof and their use as pharmaceutical compositions.

2&prime;-Halo-3&prime;,5&prime;-dialkoxyphen-1&prime;-yl-imino-2-imidazolidine and the use thereof as a drug

A method of treating urinary incontinence in a patient in need thereof, the method comprising administering to the patient an effective amount of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol or a pharmacologically acceptable salt thereof, and pharmaceutical compositions.

Use of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol for treating urinary incontinence

The present invention relates to the use of &agr;,-agonists for treating urinary incontinence.

Growing community of inventors

Fukui, Japan

Ikunobu Muramatsu