Other

Japan Science and Technology Agency

Otsuka Pharmaceutical Company, Limited

Ikumi Tamai

Akira Tsuji

Yoshimichi Sai

Hidekazu Toyobuku

Masaaki Odomi

Noubuhiko Yui

Toru Oya

Ken-ichi Miyamoto

The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.

Gastrointestinal absorption enhancer mediated by proton-coupled transporter and its preparing method

The present invention is to provide a tissue-specific transporter inhibitor which is not absorbed through the digestive tract and can prevent deterioration in the QOL of a patient caused by diet therapy, and a therapeutic drug for tissue dysfunction diseases and a therapeutic drug for suppressing the progress of chronic renal failure containing the inhibitor as an active ingredient. A tissue-specific transporter inhibitor which is not absorbed through the digestive tract is constructed by introducing a dipeptide which is a ligand of an oligopeptide transporter 1 into a supramolecular structure polyrotaxane wherein its structurally modified active residue is expected to be excellent in the interaction with a transmembrane transporter.

Tissue-specific transporter inhibitor

Growing community of inventors

Kanazawa, Japan

Ikumi Tamai