Astellas Pharma Gmbh

Cytokinetics, Inc.

Kotobuki Pharmaceutical Co Ltd

Mitobridge, Inc.

Ikumi Kuriwaki

Hiroyuki Hisamichi

Bradley Paul Morgan

Ryo Sato

Pu-Ping Lu

Scott E Collibee

Tsukasa Ishihara

Susumu Yamaki

Kazuyuki Tsuchiya

Kazuhiro Ikegai

Wenyue Wang

Ryuichi Takezawa

Takuya Makino

Toshio Kurosaki

Nobuaki Takeshita

Yuka Koizumi

Chris Evans

Makoto Yamasaki

Atsushi Suzuki

Takashi Futami

Tomoyuki Suzuki

Atsushi Noda

Hiroyuki Moritomo

Takahiro Morikawa

Takeyuki Nagashima

Hiroshi Tomiyama

Ryushi Seo

Kenji Negoro

Akio Kamikawa

Eiji Kawaminami

Kenichi Kawaguchi

Wataru Hamaguchi

Hisao Hamaguchi

Sunao Imada

Yohei Seki

Naoto Katoh

Kazuhiko Iikubo

Yoshinori Iwai

Kazuyuki Kuramoto

Tomoyoshi Imaizumi

Mitsuaki Okumura

Ryuichi Sekioka

Eriko Honjo

Makoto Asaumi

Kazuhisa Tsunoyama

Hiroki Fukudome

Kozo Miyasaka

Junko Maeda

Kazuo Tokuzaki

Jeffrey Ciavarri

Hiroki Ishioka

Yumi Yamashita

Minoru Kameda

Haruki Okada

Kai Kitamura

Kenichi Kakefuda

Yuichiro Kawamoto

Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X, X, R, R, R, R, R, and Rare as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Bicyclic 1,4-diazepanones and therapeutic uses thereof

Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X, X, R, R, R, R, R, and Rare as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

[Problem] A compound which is useful as a STING inhibitor is provided. [Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.

Aryl alkynamide derivatives

Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

Nitrogen-containing aromatic heterocyclic compound

A method for preventing or treating a disease selected from the group consisting of visceral pain, inflammatory pain, osteoarthritis pain, neuropathic pain, and fibromyalgia in a subject in need thereof, comprising administering to said subject an effective amount of the compound of the following formula (I) or a salt thereof: wherein R, R, R, R, R, X and n are as described herein.

Benzothiophene compound

The present invention is directed to compounds of Formula I: 

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Tokyo, Japan

Ikumi Kuriwaki