Chugai Seiyaku Kabushiki Kaisha

F. Hoffmann-la Roche Ag

Ikumi Hyodo

Hiroki Nishii

Lisha Wang

Tadakatsu Hayase

Masayuki Matsushita

Yoshito Nakanishi

Hirosato Ebiike

WeiLi Zhao

Masayuki Ohmori

Masami Kochi

Toshiyuki Mio

Naoki Taka

Kyoko Takami

Kenichi Kawasaki

Kazuo Hattori

Yoshiaki Isshiki

Fumio Watanabe

Kihito Hada

Toshihiro Aoki

Masaki Tomizawa

Weili Zhao

The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X, X, Xand Xare each independently —CR═ or N═, Ris, for example, a halogen atom, Ris, for example, —S(═O)—NH—R, Ris, for example, a Calkyl group, Ris, for example, a hydrogen atom, Ris, for example, a halogen atom, Ris, for example, a hydrogen atom, and Ris, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

Arylamide derivative having antitumor activity

A method for treating cancer that includes administering a pharmaceutically effective amount of a composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents a 5- to 10-membered heteroaryl group, or a Caryl group; Rand Rindependently represent H, OH, X, CN, NO, a Chaloalkyl group, a Calkyl group, or the like &#x3c;Rand Rtogether form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group&#x3e;; Rrepresents H, a Calkyl group, a Caryl group, a Calkyl group, or a Chaloalkyl group; and Rrepresents H, X, a Calkyl group, a Chaloalkyl group, OH, CN, NO, or the like. 

Aminopyrazole derivative

A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a Caryl group; Rand Rindependently represent H, OH, X, CN, NO, a Chaloalkyl group, a Calkyl group, or the like &#x3c;Rand Rtogether form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group&#x3e;; Rrepresents H, a Calkyl group, a Caryl group, a Calkyl group, or a Chaloalkyl group; and Rrepresents H, X, a Calkyl group, a Chaloalkyl group, OH, CN, NO, or the like.) 

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Kanagawa, Japan

Ikumi Hyodo