Japan Science and Technology Agency

Sankyo Company, Limited

Ikuko Shimada

Naoki Tanaka

Koichi Fujimoto

Yutaka Majima

Fumitoshi Asai

YoonYoung Choi

Ryo Toyama

Mingyue Yang

A heteroepitaxial structure includes a first metal portion having a polycrystalline structure, a second metal portion on the first metal portion, the second metal portion has an island-shaped structure on the first metal portion, the second metal portion is provided corresponding to at least one crystalline grain exposed to a surface of the first metal portion, and the second metal portion and the at least one crystalline grain have a heteroepitaxial interface.

Heteroepitaxial structure and method for forming the same, and nanogap electrode

A compound of a formula (1) and pharmacologically acceptable salts thereof:wherein Rrepresents hydrogen, halogen, alkyl or hydroxyl; Rrepresents hydrogen or halogen; Rrepresents hydrogen, alkyl, hydroxyl, carboxyalkyl, alkoxycarbonylalkyl, alkylsulfonyl, alkoxycarbonylalkylsulfonyl, craboxyalkylsulfonyl or carboxyalkylcarbonyl; each of Rand Rrepresents hydrogen, halogen, alkyl, carbamoyl, alkoxy, carboxyl, alkoxycarbonyl, monoalkylcarbamoyl or dialkylcarbamoyl; Rrepresents a heterocycle, hydrogen, alkyl, cycloalkyl, aralkyl, carboxyalkyl, alkoxycarbonyalkyl, aliphatic or aromatic acyl, carbamoyl, alkylsulfonyl, aryl, formimidoyl, 1-iminoalkyl, N-alkylforminidoyl or iminoarylmethyl; each of Rand Rrepresents hydrogen or alkyl; n represents 0, 1 or 2. The compound exhibits excellent activated blood coagulation factor X inhibitory activity and prevents or treats blood coagulation-related diseases.

Benzamidine derivatives

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Yokohama, Japan

Ikuko Shimada