Finetech Laboratories Ltd.

Fine Tech Corporation

Other

Par Pharmaceutical, Inc.

Igor Zaltzman

Arie L Gutman

Genady Nisnevich

Eleonora Shkolnik

Boris Tishin

Boris Pertsikov

Marina Etinger

Gennady Nisnevich

Lev Judovich

Lev Yudovich

Lev Yudovitch

Gennadiy Nisnevich

Gennadiy Nisnovich

Vladimir Kuznetsov

The invention provides a novel process for the preparation of prostaglandins and analogues thereof, and new crystalline intermediates in the process.

Process for the preparation of prostaglandin derivatives

The present invention provides a new and effective process for the synthesis of 17-phenyl-18,19,20-trinor-PGFand its derivatives, including the anti-glaucoma drugs Bimatoprost and Latanoprost. The benefit of the present invention rises inter alia from the fact that a major intermediate involved in the synthesis of the above compounds may be isolated from a mixture containing also an undesired isomer, by crystallization. In addition, the undesired isomer may be oxidized to give the starting compound, which is then recycled.

Process for the preparation of 17-phenyl-18,19,20-thinor-pgf 2a and its derivatives

Disclosed is a process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process.

Process for the preparation of Latanoprost

Process for making cyanomethyl ester precursors of flecainide

Polyaldimines of oligomeric aminobenzoic acid derivatives, and their use for preparation of moisture-curable, storage-stable, one-part polyreas

Process and a novel intermediate for the preparation of Flecainide

The present invention relates to a new process for the preparation of acetylcholinesterase inhibitors of formula (I) or a salt thereof, wherein: R is N-acyl-4-piperidyl; N-alkoxycarbonyl-4-piperidyl; N-alkyl-4-piperidyl; N-benzyl-4-piperidyl; N-(&ohgr;-aralkyl)-4-piperidyl; 4-pyridyl; R , R , R , and R are identical or different and each represents hydrogen, straight-chain or branched alkyl, aryl, hydroxy, alkoxy, aryloxy, benzyloxy, acyloxy, alkylthio, arylthio, benzylthio, acylamino, phthalimido or halogen; n is 1, 2 or 3; m is 1, 2, 3, 4, or 5. This process comprises cyclisation of a compound of formula (II) or salts thereof, wherein R , R , R , R and R , m and n are as defined above; R is selected from a derivatised or non-derivatised carboxyl, cyano, N-substituted aminocarbonyl groups or hydrogen; R is selected from a derivatised or non-derivatised carboxyl, cyano or N-substituted aminocarbonyl groups, optionally in the presence of acids and/or solvents. One of the most potent acetylcholinesterase inhibitors of the class of compounds prepared according to the present invention is donepezil.

Process and intermediates for production of donepezil and related compounds

Process for the preparation of flecainide

A process for producing trifluoroethoxybenzoic acids or salts thereof by reaction of halobenzoic acids or salts thereof with 2,2,2-trifluoroethanol in the presence of a strong base and copper containing materials. The compounds obtained by the process of the present invention may be used as synthetic intermediates in the pharmaceutical industry.

Process for the preparation of (2,2,2-trifluoroethoxy)benzoic acids

Growing community of inventors

Haifa, Israel

Igor Zaltzman