Clarkson University

Tufts University

Nanoscience Solutions LLC

Igor Sokolov

Milos Miljkovic

Maxim Evgenevich Dokukin

Sajo P Naik

Eun-Bum Cho

Yuri Liburkin

Shajesh Palantavida

Dmytro Volkov

William C Messner

Maxim Dokukin

Gregory Slack

Yaroslav Kievsky

Piers Echols-Jones

Vivekanand Kalaparthi

Berney Peng

A method comprises using an atomic-force microscope, acquiring a set of images associated with surfaces, and, using a machine-learning algorithm applied to the images, classifying the surfaces. As a particular example, the classification can be done in a way that relies on surface parameters derived from the images rather than using the images directly.

Atomic-force microscopy for identification of surfaces

This application discloses the approach of synthesizing cellulose acetate nanoparticles and rods which may have a chemically functionalized surface and an encapsulated cargo load. Functionalization and/or loading of the cargo are made through a physical mixing of the functionalizing and/or cargo components in the synthesizing bath. This can result in particles with functionalized surfaces with various functional groups, as well as active cargo load encapsulated in the particles. The encapsulated cargo includes but is not limited to biologically, chemically, and optically active substances.

Functionalized nanoparticles having encapsulated guest cargo and methods for making the same

A method of carrying out sub-resonant tapping in an atomic force microscope includes causing a probe that is disposed above a sample to be translated in a direction parallel to a horizontal plane defined by the sample and to oscillate in a vertical direction that is perpendicular to the horizontal plane about an equilibrium line that is separated from the horizontal plane by a vertical offset. As a result, the probe repeatedly taps a surface of the sample. Each tap begins with a first contact of the probe on the surface followed by a progressive increase in force exerted by the sample on the probe until a peak force is attained. The vertical offset is controlled by relying at least in part on a feature other than the peak force as a basis for controlling the vertical offset.

Feedback correction in sub-resonant tapping mode of an atomic force microscope

This invention describes the self-assembly of meso(nano)porous silica particles from inorganic an inexpensive silica precursor, sodium silicate. The particles have a well defined shape, high surface area, and high uniformity of the pore size, the properties that are typically found for high quality mesoporous material synthesized from organic silica precursors. The disclosure illustrates a synthesis of hard spheres, discoids, and a mixture comprising discoids, gyroids and fibers, termed as origami.

Synthesis of mesoporous silica shapes using sodium silicate as a silica source

This invention comprises methods, systems, and devices for tagging objects with one or more particles of complex geometry, individually and in combination. The particles are created via the process of either artificial or biological/natural self-assembly and are used for tagging or labeling various goods in order to identify those goods. The particles may be used individually or in combination as a plurality of particles which are scattered or positioned in a pattern. For example, the use of ultrabright fluorescent silica particles comprising complex optical fluorescent spectra and/or geometrical shapes to tag and authorize objects is disclosed. Application methods and materials are disclosed as well as methods and devices for detecting and decoding resulting tags or labels.

Tagging of materials and goods with particles of complex shapes and/or fluorescent spectra

This invention describes the encapsulation of and self-assembly of meso (nano) porous silica particles from inorganic an inexpensive silica precursor, sodium silicate. The particles have a well defined shape, high surface area, and high uniformity of the pore size, the properties that are typically found for high quality mesoporous material synthesized from organic silica precursors. The disclosure illustrates a synthesis of hard spheres, discoids, and a mixture comprising discoids, gyroids and fibers, termed as origami.

Use of self-assembled nanoporous glass colloids for prolongation of plasticity of polymeric materials

Ultrabright fluorescent silica particles that can take stable temperature measurements, and methods of their manufacture. The particles have encapsulated fluorescent substances, some of which can exhibit altering fluorescent characteristics depending on temperature. The particles function as a thermometer allowing one to measure the temperature of the environment. A ratio of the fluorescent peaks in the fluorescent spectrum of each particle depends on temperature, but is dependent on neither the amount of exciting light nor the size of the particles. Further, the particle size can be confined to the range of 8 nm to 100 &#x3bc;m.

Methods and systems for the synthesis of ultrabright fluorescent silica particles capable of measuring temperature

A method for polishing tooth surface which eases removal of a bacterial film later grown on the polished surface. The method includes the steps of providing a providing a toothpaste or slurry comprising a plurality of inorganic abrasive particles smaller than 100 nm in size, the inorganic abrasive particles comprising one or more of silica, ceria, titania, zirconia, silicon nitrite, and silica carbide, wherein the inorganic abrasive particles are sufficiently hard to be abrasive; and polishing a tooth surface with the toothpaste or slurry to attain an ultra-smooth tooth surface which can be easily cleaned.

Methods for polishing a tooth surface utilizing abrasive nanoparticles

The invention generally relates to fluorescent particles and more specifically to silica-based fluorescent nanoporous particles with physically encapsulated organic dyes. In one aspect of the invention, the nanoporous architecture provides a significant enhancement in fluorescence of the particles brightness compared to free dye. A particular chemical control of the silica matrix prevents the dye molecules from leaking the particles.

Synthesis of ultrabright fluorescent silica particles

A processing system cooperates with an atomic force microscope operating in ramp mode at a ramp frequency is configured to collect data indicative of at least one of physical and chemical properties of a sample. The system collects data indicative of probe movement at a frequency that is higher than the ramp frequency. This data comprises a second-order portion of the probe's signal. Based at least in part on the second-order portion, the processor obtains a parameter that is indicative at least one of a physical and a chemical property of a sample.

Exploitation of second-order effects in atomic force microscopy

The present invention provides an apparatus and method including hardware and software, which allows collecting and analyzing of data to obtain information about mechanical properties of soft materials. This allows surface mapping of viscoelastic properties in a high-resolution and fast manner. It also allows finding the degree of nonlinearity of the material response of the sample during the measurements. The apparatus can be used as a stand-alone device, or an add-on to either the existing atomic force microscope or nanoindenter device.

High resolution, high speed multi-frequency dynamic study of visco-elastic properites

A method is described for distinguishing between cancerous and normal human cells. The method includes collecting cells; preparing cells for scanning; scanning of the prepared cells by means of atomic force microscopy; processing of the obtained images through specific algorithms; wherein the algorithms allowing one to identify whether the cell is cancerous or normal.

Method of identification of cancerous and normal cells

The object of the invention is to producing ultras bright fluorescent silica particles by synthesizing large nanopore silica particles with self sealed channels/pores and then stopping the synthesizing before large nanopore silica particles have been formed, wherein said sintering solution has produced nanoparticles. The large nanopore silica particles are micron size. The synthesizing is stopped by diluting said synthesizing solution with a neutralizing medium such as an aqueous solution of definite acidity of pH7 and higher an exemplary value of pH11 (sodium hydroxide). The time range for stopping the synthesizing ranges from tens of seconds to ten of minutes.

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Potsdam, NY, United States of America

Igor Sokolov