Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky

Univerzita Palackeho V Olomouci

Biopatterns, S.r.o.

Freie Universitat Berlin

Igor Popa

Miroslav Strnad

Karel Dolezal

Marek Zatloukal

Lukas Spichal

René Lenobel

Stefaan Werbrouck

Jan Holub

Vladimir Krystof

Jiri Voller

Libor Havlicek

Tomas Werner

Borivoj Vojtesek

Radek Jorda

Frank J Massino

Dana Hradecká

Stjepan Uldrijan

Petr Mlejnek

Novel heterocyclic derivatives based on N-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

[object Object]

The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines. 

Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and compositions containing these derivatives

The invention concerns novel substitution derivatives of N-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.

Heterocyclic derivatives based on N-substituted adenine of, e.g.,a formula: wherein R2 is hydrogen, R6 is R6'-X, X is &#x2014;NH&#x2014;, and R6&#x2032; is substituted phenyl or substituted benzyl. The derivatives possess anticancer, mitotic, imunosuppressive and antisenescent properties for plant, animal and human cells, and methods of their preparation are disclosed. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

Growing community of inventors

Olomouc, Czechia

Igor Popa