Lam Research Corporation

Invisage Technologies, Inc.

Blue29 Corporation

Intermolecular, Inc.

Axbio Inc.

Kla-tencor Technologies Corporation

Igor C Ivanov

Hui Tian

Edward Hartley Sargent

Artur Kolics

Jonathan Xiaohang Zhang

Weiguo Zhang

Tony P Chiang

Jess Jan Young Lee

Michael Ross Malone

Pierre Henri Rene Della Nave

Michael Charles Brading

Zhi-Wen Sun

Chiu H Ting

Bob Kong

Prashant B Phatak

Alexander A Gorer

Vladimir Ivanovich Bashkirov

Nicolai Petrov

Albert Chueh

Suhua Deng

Rajsapan Jain

Jinhong Tong

Ron Rulkens

Robert D Tas

Shashank Ravindra Kulkarni

Licheng Niu

Sergey D Lopatin

Robert W Fiordalice

Faivel S Pintchovski

Stephen F Dreyer

Wen Zhong Kong

Edward H Sargent

Priyanka Agrawal

Arthur Kolics

Welguo Zhang

The present disclosure provides methods for processing a nucleic acid sample. For example, a method of the present disclosure may simultaneously process two populations of nucleic acid (NA) templates for two different sequencing modalities: (i) a first population comprising circularized NA templates having a size smaller than a size threshold (e.g., smaller than 2 kilobase (kb)), and (ii) a second population comprising uncircularized NA templates having a size greater than or equal to the size threshold.

Methods for processing a nucleic acid sample and compositions thereof

The present disclosure provides a method and systems for processing or analyzing a nucleic acid molecule. A method for processing or analyzing a double-stranded nucleic molecule may comprise providing the double-stranded nucleic acid molecule and a double-stranded adapter. The double-stranded adapter may comprise a nicking site within a sense strand or an anti-sense strand of the double-stranded adapter. The double-stranded adapter may then be coupled to the double-stranded nucleic acid molecule, and the double-stranded nucleic acid molecule coupled to the double-stranded adapter may be circularized to generate a circularized double-stranded nucleic acid molecule.

Methods, systems, and compositions for nucelic acid sequencing

Methods, systems, and compositions for nucleic acid sequencing

Diagnostic systems for sensing biological molecules are disclosed. The diagnostic systems include a fluid control delivery and control system that can be coupled to a diagnostic cartridge that includes a microfluidic device and integrated sensing electronics. The diagnostic systems can be used to sequence biological molecules.

Biomolecule diagnostic systems

Devices, apparatus and methods for sequencing macromolecules are disclosed. The devices and apparatus include independently controllable fluid channels bi-directionally coupled to a measurement module.

Apparatus and methods for continuous diagnostics of macromolecules

Various embodiments include methods and apparatuses for forming and using pixels for image sensors. In one embodiment, an image sensor having at least two pixel electrodes per color region, and having at least two modes is disclosed. The example image sensor includes a first, unbinned, mode; and a second, binned, mode. In the first, unbinned mode, the at least two pixel electrodes per color region are to be reset to substantially similar levels. In the second, binned mode, a first pixel electrode of the at the least two pixel electrodes is to be reset to a high voltage that results in efficient collection of photocharge, and a second pixel electrode of the at the least two pixel electrodes is to be reset to a low voltage that results in less efficient collection of photocharge. Other methods and apparatuses are disclosed.

Layout and operation of pixels for image sensors

An image sensor device includes a semiconductor substrate, including an array of pixel circuits, which define respective pixels of the device. A photosensitive layer is formed over the semiconductor substrate and configured to transfer charge to the pixel circuits in response to light incident on the photosensitive layer. An upper layer is formed over the photosensitive layer and is at least partially transparent to the light. Opaque partitions extend vertically through the upper layer in a checkerboard pattern aligned with the pixels in the array.

Image sensors employing sensitized semiconductor diodes

Optically sensitive devices include a device comprising a first contact and a second contact, each having a work function, and an optically sensitive material between the first contact and the second contact. The optically sensitive material comprises a p-type semiconductor, and the optically sensitive material has a work function. Circuitry applies a bias voltage between the first contact and the second contact. The optically sensitive material has an electron lifetime that is greater than the electron transit time from the first contact to the second contact when the bias is applied between the first contact and the second contact. The first contact provides injection of electrons and blocking the extraction of holes. The interface between the first contact and the optically sensitive material provides a surface recombination velocity less than 1 cm/s.

Materials, fabrication equipment, and methods for stable, sensitive photodetectors and image sensors made therefrom

Devices for use in determining properties of biochemicals and macromolecules derived from a biological sample include a fluid control unit and a macromolecule measurement unit integrated on a monolithic platform. Devices and methods of measuring the properties of macromolecules using immobilized magnetic particles are also disclosed.

Devices and methods for measuring the properties of macromolecules

In various embodiments, an imaging system and method are provided. In an embodiment, the system comprises a first image sensor array, a first optical system to project a first image on the first image sensor array, the first optical system having a first zoom level. A second optical system is to project a second image on a second image sensor array, the second optical system having a second zoom level. The second image sensor array and the second optical system are pointed in the same direction as the first image sensor array and the first optical system. The second zoom level is greater than the first zoom level such that the second image projected onto the second image sensor array is a zoomed-in portion of the first image projected on the first image sensor array.

Devices and methods for high-resolution image and video capture

In various example embodiments, the inventive subject matter is an image sensor and methods of formation of image sensors. In an embodiment, the image sensor comprises a semiconductor substrate and a plurality of pixel regions. Each of the pixel regions includes an optically sensitive material over the substrate with the optically sensitive material positioned to receive light. A pixel circuit for each pixel region is also included in the sensor. Each pixel circuit comprises a charge store formed on the semiconductor substrate and a read out circuit. A non-metallic contact region is between the charge store and the optically sensitive material of the respective pixel region, the charge store being in electrical communication with the optically sensitive material of the respective pixel region through the non-metallic contact region.

In various embodiments, a photodetector includes a semiconductor substrate and a plurality of pixel regions. Each of the plurality of pixel regions comprises an optically sensitive layer over the semiconductor substrate. A pixel circuit is formed for each of the plurality of pixel regions. Each pixel circuit includes a pinned photodiode, a charge store, and a read out circuit for each of the plurality pixel regions. The optically sensitive layer is in electrical communication with a portion of a silicon diode to form the pinned photodiode. A potential difference between two electrodes in communication with the optically sensitive layer associated with a pixel region exhibits a time-dependent bias; a biasing during a first film reset period being different from a biasing during a second integration period.

Photodetector comprising a pinned photodiode that is formed by an optically sensitive layer and a silicon diode

A method is provided which includes dispensing and removing different deposition solutions during an electroless deposition process to form different sub-films of a composite layer. Another method includes forming a film by an electroless deposition process and subsequently annealing the microelectronic topography to induce diffusion of an element within the film. Yet another method includes reiterating different mechanisms of deposition growth, namely interfacial electroless reduction and chemical adsorption, from a single deposition solution to form different sub-films of a composite layer. A microelectronic topography resulting from one or more of the methods includes a film formed in contact with a structure having a bulk concentration of a first element. The film has periodic successions of regions each comprising a region with a concentration of a second element greater than a set amount and a region with a concentration of the second element less than the set amount.

Methods for forming a barrier layer with periodic concentrations of elements and structures resulting thereform

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Dublin, CA, United States of America

Igor C Ivanov