The University of Texas System

Igor Almeida

Rosa Maldonado

Katja Michael

Nathaniel Schocker

Carylinda Serna

Susana Portillo

Eva Adriana Iniguez

Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-&#x3b1;(1,2)-R, Galp-&#x3b1;(1,3)-R, Galp-&#x3b1;(1,4)-R, or Galp-&#x3b1;(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treatinginfections. In certain aspects, the glycoconjugates as described herein, are incorporated into pharmaceutical compositions or vaccines

Glycoconjugate vaccine for

Certain embodiments are directed to method for synthesizing and using glycoconjugates based on the immunodominant epitope Gal&#x3b1;(1,3)Gal&#x3b2;(1,4)GlcNAc&#x3b1; (Gal&#x3b1;3LN&#x3b1;).

Glycoconjugates and methods for their use

Certain embodiments are directed to method for synthesizing and using glycoconjugates on the immunodominant epitope Gal&#x3b1;(1,3)Gal&#x3b2;(3(1,4)GlcNAc&#x3b1; (Gal&#x3b1;3LN&#x3b1;).

Use of synthetic peptides derived fromantigens and their use in vaccination against trypomastigote infection and Chagas disease.uses several surface proteins to invade the host. In their role of protection, the surface protients ensure the targeting and invasion of specific cells or tissues. A conserved region in the family of mucin-associated surface proteins (MASP) was used to analyze the expression of MASP at different points of invasion and proved to be important for host cell invasion, thus suggesting MASP as a candidate for vaccine development. A synthetic peptide, MASPsyn, was studied and showed efficacy in stimulating antibody and cytokine production necessary for resistance against the parasite.

Growing community of inventors

El Paso, TX, United States of America

Igor Almeida