Dow Agrosciences LLC

Other

The Dow Chemical Company

Doe Agrosciences LLC

Ignacio Mario Larrinua

Kenneth Edwin Narva

Aaron Todd Woosley

Timothy Denver Hey

Navin Elango

Huarong Li

Chaoxian Geng

Monica Britt Olson

Justin Michael Lira

Scott Bevan

Avutu Sambi Reddy

Vipula Shukla

Donald J Merlo

Matthew J Henry

Lining Guo

Jon Christopher Mitchell

Scott A Young

Scott B Bintrim

Barry W Schafer

Patricia C Apel-Birkhold

James Patrick Connell

Susan B Green

Thomas Meade

Holly Jean Butler

Stephanie L Burton

Daniel Gachotte

Randy J Pell

Avutu S Reddy

Barbara A Miller

Beth Blakeslee

David A McCrery

J Vincent B Oriedo

Rodney Crosley

Pamela Rene Haygood

Zihua Hu

Arvind Kumar Thirumalaiswamysekhar

Joel Jay Sheets

Sean Michael Russell

Gregory P Pogue

Kelley Ann Smith

Guy R Della-Cioppa

Murugesan Rangasamy

Philip J Savickas

Weiting W Ni

Max Otto Ruegger

Xiaoping Xu

Meghan L F Frey

Cristie Min Dewes

Theodore Jack Letherer

Monica Britt-Olson

Kelley L Ralph

Mathew J Henry

Thaddeus Weglarz

Arvind Kumar ThirumalaiswamySekhar

Anthony Trieu

Ted Weglarz

Wenjin Zheng

Gerson Wolfe

Anthony Thinh Ngoc Trieu

Christie Min Dewes

Anvid Kumar Thirumalaiswamysekhar

DIG-303 insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed.

Dig-303 insecticidal Cry toxins

This disclosure concerns methods for the design of synthetic nucleic acid sequences that encode polypeptide amino acid repeat regions. This disclosure also concerns the use of such sequences to express a polypeptide of interest that comprises amino acid repeat regions, and organisms comprising such sequences.

Process for designing diverged, codon-optimized large repeated DNA sequences

This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.

Nucleic acid molecules that target the vacuolar atpase C subunit and confer resistance to coleopteran pests

Nucleic acid molecules that target RPA70 and confer resistance to coleopteran pests

Nucleic acid molecules that confer resistance to coleopteran pests

Nucleic acid molecules that target PP1-87B and confer resistance to coleopteran pests

Nucleic acid molecules that target RPS6 and confer resistance to coleopteran pests

DIG-10 Cry toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed.

DIG-10 insecticidal cry toxins

The present invention includes domain I modifications that improve various attributes of various Coleopteran-active Cry proteins. These attributes can include improved target pest spectrum, potency, and insect resistance management. The subject modifications can affect protoxin activation and the efficiency of pore formation, which can lead to enhanced insect intoxication.

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The invention provides synthetic nucleic acid sequences encoding proteins of interest that are particularly adapted to express well in plants. The claimed synthetic sequences utilize plant-optimized codons roughly in the same frequency at which they are utilized, on average, in genes naturally occurring in the plant species. The invention further includes synthetic DNA sequence for herbicide tolerance, water and/or heat stress tolerance, healthy oil modifications and for transformation marker genes and selectable marker genes are used. DNA construct and transgenic plants containing the synthetic sequences are taught as are methods and compositions for using the plants in agriculture.

Synthetic genes

The present invention includes modified, insecticidal B.t. Cry1Ca proteins, including the proteins designated herein as DIG-109 and DIG-152, as well as variants of DIG-109 and DIG-152, nucleic acids encoding these proteins, methods of controlling pests using the proteins, methods of producing the proteins in transgenic host cells, and transgenic plants that produce the proteins. The DIG-109 and DIG-152 proteins comprise chimeric peptides composed of a core toxin segment of B.t. Cry1Ca and a Cry1Ab protoxin segment. Insecticidally active variants of the DIG-109 and DIG-152 proteins are also described.

Modified Cry1Ca insecticial Cry proteins

Nucleic acid molecules that target the RHO1 small GTP-binding protein and confer resistance to coleopteran pests

Nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests are disclosed. Methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby are also disclosed.

Nucleic acid molecules that target the vacuolar ATPase H subunit and confer resistance to coleopteran pests

Growing community of inventors

Indianapolis, IN, United States of America

Ignacio Mario Larrinua