Johns Hopkins University

Ie-Ming Shih

Tza-Huei J Wang

Mark Vaal

Kelvin J Liu

Jin G Jung

Tian-Li Wang

Alexander Stoeck

In accordance with one or more embodiments, the present invention provides a compound of formulas I, II, and III, for use in methods of inhibition of PBX1-DNA interaction in a mammalian cell or population of cells, and for use in the treatment of medical conditions including but not limited to cancers, developmental disorders, inflammatory disorders, autoimmune diseases, or neuro-degenerative disorders.

Small molecule compounds targeting PBX1 transcriptional complex

The present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dye in a stoichiometric manner, subjecting the DNA to molecular spectroscopy (e.g., cylindrical illumination confocal spectroscopy), analyzing suitable fluorescent burst parameters of the labeled DNA, and conducting single molecule DNA integrity analysis of the labeled DNA molecules in the sample. In one embodiment of the invention, the method is used as a diagnostic method for detecting cancer.

DNA integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy

Growing community of inventors

Clarksville, MD, United States of America

Ie-Ming Shih