Technology Innovation Momentum Fund (Israel) Limited Partnership

Ido Yosef

Ehud Qimron

Miriam Manor

Moran Goren

Provided is a platform for of the preparation of improved nucleic acid delivery vehicles, specifically, vehicles having an extended host recognition ability. Further provided are improved vehicles, compositions and uses thereof.

Bacteriophage variants having extended host-range, methods for preparation and uses thereof in transducing nucleic acids into hosts of interest

Provided is a kit or a system including two elements or components. The first component (i) is a selective component including a nucleic acid sequence and at least one proto-spacer. The second component (ii) includes at least one sensitizing component including at least one cas gene and at least one CRISPR array. At least one spacer of the CRISPR targets a proto-spacer included within a pathogenic gene of a bacterium so as to specifically inactivate said pathogenic gene in said bacterium and wherein at least one spacer of said CRISPR targets a proto-spacer included within said selective component of (i) so as to specifically inactivate said selective component. Further provided is a method using the components or kits of the invention for interference with a horizontal transfer of a pathogenic gene between bacteria and for preventing a pathologic condition in a mammalian subject caused by a bacterial infection.

Growing community of inventors

Moshav Netiv Ha'Asara, Israel

Ido Yosef