S.d. Sight Diagnostics Ltd.

Other

Harvard College

Bar-Ilan University

Massachusetts Institute of Technology

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Northeastern University

Dimes - Dipartimento Do Medicina Sperimentale - Universita Degli Studi Di Genova

Dimes-Dipartimento Do Medicina Sperimentale

Ido Bachelet

Daniel Levner

Joseph Joel Pollak

Yonatan Bilu

Noam Yorav-Raphael

Yaniv Amir

Ariel Munitz

Almogit Abu-Horowitz

George M Church

Anastasia Shapiro

Eldad Ben-Ishay

Francesca Levi-Schaffer

Zeev Zalevsky

Ram Sasisekharan

Marc Elliot Rothenberg

Alessandro Moretta

Amir Shemer

Francois Vigneault

Joel De Beer

Lorenzo Moretta

Uri Laserson

Shawn M Douglas

Shmulik Ittah

Erez Lavi

Noam Mamet

Itai Rusinek

Mark Bulmer

Gil Harari

Rebeca B Rosengaus

Apparatus and methods are described including successively acquiring a plurality of microscopic images of a portion of a blood sample, and tracking motion of pixels within the successively acquired microscopic images. Trypomastigote parasite candidates within the blood sample are identified, by identifying pixel motion that is typical of trypomastigote parasites. It is determined that the blood sample is infected with trypomastigote parasites, at least partially in response thereto. An output is generated indicating that that the blood sample is infected with trypomastigote parasites. Other applications are also described.

Apparatus and method for analyzing a bodily sample

Apparatus and methods are described for use with a digital camera that is configured to acquire images of a bodily sample. Two or more stains are configured to stain the bodily sample. A computer processor drives the digital camera to acquire, for each of a plurality of imaging fields of the bodily sample, two or more digital images, at least one of the images being acquired under brightfield lighting conditions, and at least one of the images being acquired under fluorescent lighting conditions. The computer processor performs image processing on the digital images, by extracting visual classification features from the digital images and analyzing the extracted visual classification features. The computer processor outputs a result of the image processing that includes an indication of one or more entities that are contained within the sample. Other applications are also described.

The present disclosure describes compositions and methods for rapid selection of both binding and functional oligonucleotides (DNA, RNA, or any natural or synthetic analog of these). In certain embodiments, provided herein are flow cells (e.g., flow cells for an Illumina sequencing instrument or a Polonator sequencing instrument) comprising within its flow chamber a plurality of immobilized aptamer clusters (e.g., from an aptamer library described herein) and, optionally, one or more target cells (e.g., cancer cells, immune cells, etc.) and/or a detectable indicator of cellular function (e.g., a fluorescent indicator of apoptosis, cell proliferation, gene or protein expression, etc.). In certain embodiments, provided herein are methods of using such an aptamer cluster-containing flow cell to identify functional aptamers from an aptamer library (e.g., in a sequencing instrument, such as an Illumina sequencing instrument).

Methods and compositions for selection of functional oligonucleotides

Nucleic acid origami devices are provided that are non-immunogenic and/or resistant to nucleases, which may be activated by one or more external cues, such as ligands, glucose concentration or electromagnetic fields; or used for attenuation or prevention of internalization of cell-surface receptors or prolongation of shelf-life of active agents. Further provided are methods for treating diabetes and methods for preparing the devices.

Non-immunogenic and nuclease resistant nucleic acid origami devices and compositions thereof

Methods and compositions for determining and/or monitoring the immune state of an individual are provided.

High-throughput immune sequencing

Systems acting as logic gates and systems exhibiting quorum sensing are provided, wherein said systems comprise at least one effector nucleic acid origami device, at least one regulator nucleic acid origami device, at least one input and at least one output, and the nucleic acid origami devices are non-immunogenic and/or resistant to nucleases.

Systems comprising non-immunogenic and nuclease resistant nucleic acid origami devices for molecular computation

Provided herein are DNA origami devices useful in the targeted delivery of biologically active entities to specific cell populations.

DNA origami devices

The invention discloses an apparatus and method for automatic detection of pathogens within a sample. The apparatus and method are especially useful for high-throughput and/or low-cost detection of parasites with minimal need for trained personnel. The invention entails automated microscopic data acquisition, and performing image processing of images captured from a sample using classification algorithms. Visual classification features of structures are extracted from the image and compared to visual classification features associated with known pathogens. A determination is reached whether a pathogen is present in the sample; and if present, the pathogen may be identified to a pathogen species. Diagnosis is rapid and does not require medically trained personnel.

Apparatus and method for automatic detection of pathogens

Provided herein are compositions and kits comprising carbohydrate-based inhibitors that bind GNBP and/or inhibit &#x3b2;(1,3)-glucanase activity. Also provided are methods of using such inhibitors to protect against or treat pest infestation, as are compositions and kits comprising subparts of the carbohydrate-based inhibitors.

Compositions and methods for pest control

CD48, a surface-marker molecule present in eosinophils, is disclosed herein as a key molecule in allergic conditions, particularly in allergic airway inflammations like asthma, allergy and nasal polyposis. CD48 is thus presented as a target molecule in the treatment of said conditions. In addition, diagnostic methods, and a kit for the diagnosis of allergic inflammatory conditions are described, based on the detection of CD48 expression.

Therapeutic target and diagnostic marker for asthma and related conditions

Disclosed are bi-specific complexes aimed at inhibiting mast cells, eosinophils and/or basophils, and thus, at inhibiting allergy-type reactions. In particular, said complexes are best exemplified by bi-specific antibodies, which bind to two targets present in the same cell. One target is the inhibitory receptor IRp60. The second target is a cell-specific activator, e.g. IgE, cKIT, Fc&#x3b5;RI, IL5R or CCR3. Binding of the bi-specific antibody to its targets results in the induction of an inhibitory pathway, through the inhibition of the signaling from the activator. Compositions and uses of the bi-specific complexes are also described.

Bi-specific complexes for targeting cells involved in allergic-type reactions, compositions and uses thereof

Growing community of inventors

Modiin, Israel

Ido Bachelet