Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Astra Aktiebolag

Aktiebolaget Astra

Ida Szvoboda Nee Kanzel

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Maria Szomor Nee Wundele

Csaba Gonczi

Judit Cser Nee Kun

Laszlo Ledniczky

Judit Kun

Rudolf Szebeni

Csaba Gonczy

Gabor T Szabo

Tamas U Kallay

Csaba Huszar

Karoly Horvath

Erzsebet Molnar Nee Bako

Attila Nemeth

Erzsebet Szalay

Vera Kovacs Nee Mindler

Ferenc Sperber

Karoly Ban

Istvan Bone

Ferenc Morasz

Livia Nagy Nee Koranyi

Sandor Garaczy

Erzsebet Szabo Nee Kardos

Karol Gyure

Gyorgy Mihalovics

Gabor Kovacs

Sandor Virag

Gyula Sebestyen

Tamas Szuts

Emil Minker

Mihaly Sut

Peter Gyri

Ildiko Buttkai

Arpad Kvari

Peter Gy Ri

Arpad K Vari

Iidiko Buttkai

Gyorgy Kormoczi

Andras Kelemen

Mihaly Su

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, wherein

Process for the preparation of diphenyl ether derivatives

A process is disclosed for the preparation of a compound of the formula (XI) ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.3 alkoxy, or trifluoromethyl;

Process for the preparation of 5(6)-thio substituted benzimidazoles

Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,

Theophyllinyl-alkyl-oxadiazoles, process for the preparation thereof and

A new process is disclosed for the preparation of a compound of the formula (VIII) ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, or trifluoromethyl;

Production of thiocyanato benzimidazoles

Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are prepared by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.

Process for the preparation of arylacetic acid derivatives

New compounds of the formula (VIIIa) are disclosed ##STR1## wherein R.sup.1 is hydrogen, methyl or ethyl;

Esters of ortho-allylphenol useful for the preparation of arylacetic

Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are practiced by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.

Arylacetic acid derivatives

2-(3-Phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

Process for the preparation of 2-(3-phenoxy-phenyl)-propionic acid

A process for the preparation of anthelmintic compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen or --COOR;

Sulfur-containing benzimidazole derivatives

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Budapest, Hungary

Ida Szvoboda Nee Kanzel