Taiho Pharmaceutical Company Limited

Ichiro Yamawaki

Mitsugi Yasumoto

Kazuo Ogawa

Yuji Yamada

Akihide Koda

Junji Yamamoto

Mikio Hori

Masato Nanri

Nobuo Kasahara

Takashi Arima

Manabu Kaneda

Katsuo Takikawa

Yukio Tada

Hitoshi Saito

Naosuke Matsuura

Yoshinori Minami

Toshio Ohtani

Teruyoshi Marunaka

Tian Jie

Qi Chang-qing

Takaji Honna

Naohiko Ono

Shuichi Ueda

Sekio Nagayama

Bicyclolactam compounds, use thereof and intermediates for preparing thereof

Bicycloloactam compounds, use thereof and intermediates for preparing thereof

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2##

Bicyclolactam compounds, use thereof and intermediates for preparing

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2## .

Disclosed are a compound of the general formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom, an alkyl group or an acyl group, process for the production thereof and use thereof. The compounds have an antitumor activity, and those wherein both of R.sub.1 and R.sub.2 represent a hydrogen atom or an acyl group are novel compounds.

Substance 4181-2 and its derivatives having anti-leukemia activity

Substance 4181-2

A piperazine derivative represented by the formula (I) below ##STR1## wherein R.sup.1 is lower alkyl or phenyl, R.sup.2 is hydrogen or lower alkyl, n is an integer of 2 to 10, is useful as an effective component of anti-inflammatory agent or antiallergic agent.

Derivative of piperazine having anti-allergic and anti-inflammatory

This invention provides an amide compound represented by the formula ##STR1## wherein R.sub.1 is vinyl, 2-(methylsulfinyl)ethyl, 2-(methylsulfonyl)ethyl, 2-(2-acetylamino-2-carboxyethylthio)ethyl or 2-[2-(4-amino-4-carboxybutyrylamino)-2-(carboxymethylcarbamoyl)ethylthio]e thyl and R.sub.2 is hydrogen or lower alkyl, process for the preparation thereof, and antiallergic compositions cotaining the amide compound.

Amide compounds

Sulfonium compounds represented by the formula ##STR1## having immunostimulant activity and useful as the active components of drugs and agricultural chemicals.

Sulfonium compounds

This invention provides novel sulfonium compounds, processes for the preparation of the sulfonium compounds, and pharmacological composition containing the sulfonium compound. The compounds of this invention are useful for treating allergy.

Sulfonium compounds, processes for preparing the compounds and

Sulfonium compounds represented by the formula ##STR1## have anticancer activity, immunostimulant activity and the like, and useful as the active components of drugs and agricultural chemicals.

Growing community of inventors

Tokushima, Japan

Ichiro Yamawaki