Kabushiki Kaisha Toshiba

Canon Medical Systems Corporation

Toshiba Medical Systems Corporation

Ichiro Tono

Ikuo Uematsu

Kayoko Oomiya

Hideo Eto

Tomohiro Takase

Shingo Kasai

Isao Nawata

Kenichi Uchiyama

Shoichi Kanayama

Tsutomu Honjoh

Takeshi Yamauchi

Masami Hirata

Isao Kishimoto

Yuriko Oyama

Miki Nagatomo

Hiroshi Nishimura

Naotada Okada

Akira Sato

Makoto Saito

Isamu Nitta

Masaaki Hirakawa

Takaaki Wada

Tadahiro Nakayama

Asuka Hirano

Masato Sawada

Masanori Sugitani

A specimen measurement device which detects a measurement object material according to the present embodiment, includes: a magnetic field applicator configured to apply a magnetic field to a measurement cartridge including a substrate, a first substance fixed on the substrate and specifically reacting with the measurement object material, a magnetic particle, and a substance fixed on the magnetic particle and specifically acting with the measurement object material; a detector configured to detect light passing through the substrate; and a controller configured to control the magnetic field applicator to perform a first operation to apply a first magnetic field in a direction to move the magnetic particle away from the substrate when a specimen solution containing the measurement object material is introduced into the measurement cartridge, and then perform a second operation to apply a second magnetic field in a direction to move the magnetic particle toward the substrate.

Specimen measurement device and control method of specimen measurement device

An in-vitro diagnostic includes a housing, a storage, and a blocking agent. The housing houses a liquid including a test substance included in a sample extracted from a subject. The storage stores a substance that specifically reacts with the test substance. The blocking agent is placed to separate the container and the storage.

In-vitro diagnostic

According to one embodiment, a specimen measurement apparatus includes a detector and a control circuit, and is configured to perform a plurality of steps to measure the properties of a test substance retained in a reaction container. The detector outputs electromagnetic waves to the reaction container and detects the electromagnetic waves that vary according to the state in the reaction container. The control circuit controls transition timing between steps of the plurality of steps based on the detection result of the electromagnetic waves obtained by the detector.

Specimen measurement apparatus and specimen measurement method

According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property of specifically bonding to subject substances to be measured are fixed. Second substances having a property of specifically bonding to the subject substances are fixed to the magnetic fine particle. The magnetic field applying unit generates a magnetic field for moving the magnetic fine particles. The light source inputs a light into the optical waveguide. The light receiving element receives the light output from the optical waveguide.

Measuring system using optical waveguide, measuring device, measuring method, optical waveguide type sensor chip, and magnetic fine particle

An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.

Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor

An optical sensor () includes a sensor chip member () having an optical waveguide layer (), a combination of an incidence end grating () and an output end grating () spaced from each other, in contact with the optical waveguide layer (), and a reaction reagent () provided on the optical waveguide layer () to detect as an optical change a quantity of measurement object interposed between the incidence end grating () and the output end grating (), and a chamber member () to have, when the sensor chip member () is assembled, a facing surface (F) in position facing the optical waveguide layer (), and a gap (I) defined between the optical waveguide layer () and the facing surface (F), the reaction reagent () being disposed in the gap (I).

Optical sensor

An optical biosensor has a total reflection plate so as to totally internally reflect and transmit an incident light, a first grating and a second grating disposed separately on the total reflection plate, and a sensing membrane that is containing an enzyme and a chromogenic reagent and is sandwiched by the first and second gratings on the total reflection plate.

Optical biosensor

A method of preparing a coating solution for a glucose sensing membrane, the method comprising preserving a first solution containing an oxidizing enzyme or a reducing enzyme of glucose and a reagent for generating a substance for coloring a coloring agent dissolved in a buffer solution, preserving a second solution containing a mixed solution of an alcohol solution of the coloring agent and a solution of a membrane-forming polymer compound, and mixing the first solution and the second solution.

Coating solution for glucose sensing membrane and method of manufacturing optical glucose sensor chip

The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the antibody immobilized layer of the sensor chip having an immobilized antibody, producing a color-developing and precipitating enzyme reaction product by allowing to react a coloring reagent with the labeling enzyme on the antibody immobilized layer to precipitate the enzyme reaction product on the antibody immobilized layer, allowing to totally reflect a light impinged on the sensor chip from the outside at an interface between the optical waveguide layer and the antibody immobilized layer, and observing to a physical value of the totally reflected light.

Concentration measuring method, concentration measuring kit, and sensor chip for use in the method

An optical waveguide type iontophoresis sensor chip has a substrate having a first hinged plate and a second hinged plate, an optical waveguide plate connected to the first hinged plate and positioned over a first opening delineated in the first hinged plate, and a gel layer fixed on the second hinged plate and covering a second opening delineated in the second hinged plate and configured to contact with the optical waveguide plate through the first opening in case that the substrate is folded.

Optical waveguide type iontophoresis sensor chip and method for packaging sensor chip

An optical waveguide type biochemical sensor chip includes a light beam transmittable substrate having at least a first optical element that allows light beam to be impinged to the inside and a second optical element that emits light beam from the inside, an optical waveguide layer that is formed on a main surface of the substrate on which at least one of the first and second optical elements is formed, has a thickness of 3 to 300 &#x3bc;m and is made of a polymer resin material having a higher refractive index than that of the substrate material, and a sensing membrane that is formed on the optical waveguide layer and creates a reaction product having the ability of absorbing the light beam or an evanescent wave of the light beam in response to an introduced specimen.

Optical waveguide type biochemical sensor chip and method of manufacturing the same

An optical waveguide sensor for glucose measurement comprises a substrate, a first optical waveguide layer formed on a surface of the substrate, an entrance grating and an exit grating which are formed contacting with the first optical waveguide layer and being spaced from each other, a second optical waveguide layer located between the entrance grating and the exit grating while being in contact with the first optical waveguide layer, the second optical waveguide layer having a higher refractive index than that of the first optical waveguide layer, and a functioning layer containing an enzyme and a coloring reagent which is formed on the second optical waveguide layer.

Optical waveguide sensor, device, system and method for glucose measurement

An optical waveguide sensor for glucose measurement comprises a substrate, a first optical waveguide layer formed on a surface of the substrate, an entrance grating and an exit grating which are formed contacting with the first optical waveguide layer and being spaced from each other, a second optical waveguide layer located between the entrance grating and the exit grating while being in contact with the first optical waveguide layer, the second optical waveguide layer having a higher refractive index that that of the first optical waveguide layer, and a functioning layer containing an enzyme and a coloring reagent which is formed on the second optical waveguide layer.

An ink jet head includes a nozzle plate having a nozzle hole and a film having at least one of a water repellent function and an oil repellent function formed on one plate face thereof. The film includes a metal oxide and fluorine based resin.

Growing community of inventors

Yokohama, Japan

Ichiro Tono