Kao Corporation

Ichiro Tokimitsu

Atsushi Suzuki

Ryuji Ochiai

Toshiyuki Suzuki

Hiroshi Kusuoku

Akira Yamamuro

Yoshiya Sugai

Tadashi Hase

Masahide Hoshino

Koji Yoshino

Youichi Arai

Atsuko Otsuka

Noriko Otsuka

Shinichi Meguro

Tsuyoshi Otomo

Hiroko Takei

Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, Rand Rare the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, Rrepresents hydroxyl, ester bond residue, or amide bond residue, Rrepresents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid). When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.

Remedy for hypertension

Products and compositions for preventing or reducing the severity of hypertension. These products contain (a) ferulic acid or a ferulate ester, and (b) caffeic acid and/or a chlorogenic acid. The preventive or remedy can suppress a rise in blood pressure and alleviate hypertension, and is usable as a food.

Compositions and methods for alleviating hypertension or preventing a rise in blood pressure

Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, Rand Rare the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, Rrepresents hydroxyl, ester bond residue, or amide bond residue, Rrepresents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid).

Preventive or remedy for hypertension

The invention relates to an agent for preventing, improving or treating hypertension, which exhibits a hypotensive effect, inhibits the rise of blood pressure and improves hypertension, and food for preventing or improving hypertension, which does not become a burden in daily intake, has a higher antihypertensive effect and is useful as a diet during treatment for patients of hypertension. The agent for preventing, improving or treating hypertension contains the following components (A) and (B):

Agent for preventing, improving or treating hypertension

Provided is a mineral absorption enhancing method comprising administering an effective amount of a green coffee bean extract. The present invention can relieve mineral deficiency by using a mineral absorption enhancer which is excellent in safety and has an excellent mineral absorption enhancing effect.

Mineral absorption enhancer

Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2):wherein, Rand Rare the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, Rrepresents hydroxyl, ester bond residue, or amide bond residue, Rrepresents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid). When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.

A method for treating hypertension, a cardiac disease, or a cerebrovascular disease comprising administration of ferulic acid or a derivative thereof, to a subject in need of treatment. Therapeutic compositions comprising ferulic acid and its derivatives may comprise pharmaceutical products, nutritional supplements or products, and foods. Such compositions may further comprising diglycerides in combination with ferulic acid and its derivatives.

Method of treating hypertension

An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.

Amide derivatives and their use in cosmetic composition

An emulsion-type aqueous cosmetic composition comprising:

Aqueous cosmetic composition and preparation method thereof

A transparent or semitransparent jelly-like cosmetic composition comprises a monoalkyl phosphate having a .beta.-branched alkyl group, water, an oil which is liquid at room temperature, and an alcohol. The cosmetic composition is highly safe and has good moisturizing effect. Therefore, it can be used as a base for a massage cream, a body treatment, a hand cream, a hair conditioner and the like.

Growing community of inventors

Haga-gun, Japan

Ichiro Tokimitsu