Fujisawa Pharmaceutical Company, Ltd.

Toyo Tire Rubber Co., Ltd.

Astellas Pharma Gmbh

Ichiro Shima

Keiji Hemmi

Takehiko Ohkawa

Hirokazu Tanaka

Kentaro Sato

Kazuhiko Ohne

Naoki Ishibashi

Kenichiro Imamura

Keisuke Imai

Masashi Hashimoto

Yuki Sawada

Akio Kuroda

Naoki Fukami

Toshio Kurosaki

Aiko Wada

Tire

A pneumatic tire has a bead filler, a carcass ply, a side wall rubber and a rim strip rubber. The rim strip rubber has a main portion arranged in an outer side in a tire width direction of the bead filler, and a thin portion arranged between the carcass ply and the side wall rubber. The main portion forms an outer surface of a bead portion. The thin portion extends in the tire diametrical direction at a substantially fixed thickness. An upper end of the thin portion is positioned in an outer side in the tire diametrical direction than an upper end of the bead filler and in an inner side in the tire diametrical direction than a roll-up end of the carcass ply.

Pneumatic tire with specified rim strip rubber arrangement

A pneumatic tire is provided with a main groove extending along a tire circumferential direction, and a land portion comparted by the main groove in a tread surface. A reinforcing member having a cord which is inclined at an angle between 75 and 90 degrees with respect to the tire circumferential direction is buried in the vicinity of a groove bottom height of the main groove in an inner region of the land portion.

Pneumatic tire having land portion with buried reinforcing member

A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein

2-cyanopyrrolidinecarboxamide compound

The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals 

Peptide compounds

Substituted dipeptides having nos inhibiting activity

This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity, etc., and represented by general formula &lsqb;I&rsqb;.

Aminopiperazine derivatives

Trifluoromethylketone compounds of the formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6)alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6)alkyl, R.sup.2 and R.sup.3 are each C.sub.1-6 alkyl, X is --or --NH--, and ##STR2## and pharmaceutically acceptable salts thereof are useful for inhibiting human elastase.

Elastase-inhibiting peptides bearing a C-terminal trifluoromethylketone

The trifluoromethylketone derivatives (I) and pharmaceutically acceptable salts thereof have a human leukocyte elastase inhibiting activity and are useful as human leukocyte elastase inhibitors for treating or preventing degenerative diseases. The trifluoromethylketone derivatives (I) have the following formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6) alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6) alkyl,

Trifluoromethylketone derivatives, processes for preparation thereof and

The invention relates to thiazepine derivatives, which are antagonists of platelet activating factor, of the formula: ##STR1## wherein R.sup.1 is ar(lower)alkyl which may have suitable substituent(s),

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Osaka, Japan

Ichiro Shima