Labo Juversa Co., Ltd.

Other

Bioserentach Co., Ltd.

Nissha Printing Co., Ltd.

Hoya Technosurgical Corporation

Nissha Co., Ltd.

Ichiro Ono

Kanji Takada

Shinya Yamada

Keita Abe

Masanori Nakasu

Hiroyuki Nagai

Masateru Chiyama

Takako Ueno

Osanobu Akao

Kensaku Akita

Yuko Ide

Sachi Nagai

Risa Nakaoka

Yoshikiyo Akasaka

Takehiko Nakajima

To achieve stable administration of a medicine into a dermis by improving the operability of a device that inserts a microneedle into a skin. An impacting type applicator () for a microneedle patch is an applicator that applies a microneedle patch () to a skin includes a main body (), a spring expanding/compressing lever (), a resilient body (), a lock mechanism (), and a piercing switch (). The spring expanding/compressing lever () is movably attached to the main body (), and the microneedle patch () can be attached to a leading end of the spring expanding/compressing lever (). The resilient body () is a member that imparts a biasing force to the spring expanding/compressing lever (). The lock mechanism () is a mechanism that locks the spring expanding/compressing lever () in a state where the resilient body () exerts the biasing force on the main body (). The piercing switch () is a member that releases the engagement between the lock mechanism () and the spring expanding/compressing lever (). In addition, a biasing force imparting mechanism () further imparts a biasing force to the spring expanding/compressing lever () in a state where the spring expanding/compressing lever () is moved toward the leading end of the main body () and thereby presses the microneedle patch () against the skin.

Impacting type applicator for microneedle patch and leading end member

A product having a microneedle array is provided wherein the composition distribution has been adjusted with good accuracy. A droplet-delivery apparatus of a microneedle-array manufacturing apparatus is configured capable of delivering, to each recessed part, droplets of a raw-material liquid in a prescribed amount that is less than the capacity of the recessed part. An aligning apparatus can align the relative position of the droplet-delivery apparatus and a mold such that the droplets from the droplet-delivery apparatus are caused to land in each of the recessed parts. The droplet-delivery apparatus delivers a plurality of the droplets to each of the recessed parts; and the aligning apparatus aligns the relative position of the droplet-delivery apparatus and the mold such that a second droplet lands in each of the recessed parts on the center part side of a first droplet.

Microneedle-array manufacturing apparatus, microneedle-array manufacturing method, and product having the microneedle array

The invention is a microneedle preparation administration apparatus comprising: a guide tube; a pedestal in which at least a part thereof including a front end surface is housed within the guide tube and slides in length direction; and driving means for driving the pedestal toward a front end part of the guide tube, and microneedle preparations being to be attached to the front end surface of the pedestal.

Microneedle preparation administration member for placement of objective substance in dermis, and apparatus for quick administration of microneedle preparation

A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.

Microneedle assembly formulation for skin treatment

It is to provide a method for treating skin aging, or a method for treating skin scar that can exert a sufficient effect. A composition for treating skin aging comprising bFGF for treating aging of the skin that is administered intradermally or subcutaneously, or a composition for treating skin scar comprising bFGF for treating scar of skin that is administered intradermally or subcutaneously is utilized. Preferred examples of aging of skin include skin wrinkle, pigmented spot, sagging skin, rough skin, skin thinning, decrease of skin viscoelasticity, etc., and preferred examples of scar include keloid, hypertrophic scar, scar contracture, etc.

Method for treating keloid and hypertrophic scars by administration of bFGF

An organ regeneration device adapted to be used by placing it into a defective portion of an organ to regenerate the organ is provided. The organ regeneration device has a base body having a shape corresponding to a shape of the defective portion of the organ. The organ regeneration device also has particles carried on the base body, wherein the particles are composed of a different material from that of the base body. The organ regeneration device also has a growth-related substance contained in the organ regeneration device for growth and differentiation of cells around the defective portion. The growth-related substance contains an angiogenesis factor. Further, the growth-related substance contains nucleic acid containing a base sequence coding for amino-acid sequence of a growth factor different from the angiogenesis factor. Furthermore, the nucleic acid is introduced into a host cell.

Organ regeneration device

Method for treating skin aging by administration of bFGF

A method for forming an implant having a desired shape includes the steps of (a) forming a layer of ingredient powder having a predetermined thickness composed of an ingredient powder, and (b) applying an reactant liquid to the layer in accordance with the desired shape of the implant, portions of the ingredient powder reacting with the reactant liquid being hardened. The above steps are repeated to stack a plurality of the layers having hardened portions, respectively, to form a three-dimensional implant formed by a stack of the hardened portions of the layers of the ingredient powder. The ingredient powder is a powder including at least one of a-tricalcium phosphate and tetracalcium phosphate, and a Ca/P ratio of the powder is within a range of 1.40 through 2.0.

Implant forming method

Growing community of inventors

Hokkaido, Japan

Ichiro Ono