Asahi Kasei Medical Co., Ltd.

Ichiro Koguma

Fujiharu Nagoya

Hiroki Taniguchi

Teruo Okano

Yoshikatsu Akiyama

Hiroki Shigematsu

Kenichi Nagase

Kazuo Okuyama

Yoshiro Yokoyama

Izumi Hoshuyama

Masako Goto

Rumiko Ishikawa

Hiroshi Takemasa

A method for purifying a biologically active substance from a solution mixture containing impurities and the biologically active substance, in which an ion exchange chromatography carrier comprising a matrix and a copolymer containing at least N-isopropylacrylamide as a monomer unit and immobilized to a surface of the matrix is used, and the solution mixture is allowed to flow through a container storing the carrier at a uniform temperature, thereby recovering the biologically active substance.

Method for purifying antibody protein

The present invention provides a cation-exchange chromatographic support, comprising a membrane matrix and a copolymer immobilized on the surface of the membrane matrix, wherein the copolymer comprises a (meth)acrylamide-based compound and/or a (meth)acrylate-based compound as monomer units, and the support has one or more species of cation-exchange groups including at least a weak cation-exchange group at a density higher than 30 mmol/L per volume of the support.

Cation exchange chromatographic support and method for using same

Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.

Temperature responsive adsorbent having a strong cation exchange group and method for producing the same

A heat resistant microporous membrane containing a thermoplastic resin having a crystalline melting point of 140-300&#xb0; C. and having a layer structure formed in the direction of membrane thickness, said layer structure containing 5-100% of a layer defined by the following (A) and 95-0% of a layer defined by the following (B): (A) a layer in which the micropores are intra-spherulitic voids, and (B) a layer in which the micropores are intra-spherulitic voids and inter-spherulitic voids.

Heat resistant microporous film

A hydrophilic microporous membrane comprising a thermoplastic resin, having been subjected to hydrophilizing treatment and having a maximum pore size of 0 to 100 nm, wherein when 3 wt % bovine immunoglobulin having a monomer ratio of 80 wt % or more is filtered at a constant pressure of 0.3 MPa, an average permeation rate (liter/m/h) for 5 minutes from the start of filtration (briefly referred to as globulin permeation rate A) satisfies the following formula (1) and an average permeation rate (liter/m/h) for 5 minutes from the time point of 55 minutes after the start of filtration (briefly referred to as globulin permeation rate B) satisfies the following formula (2):Globulin permeation rate&#x3e;0.0015 &#xd7;maximum pore size (nm)&#x2003;&#x2003;(1)Globulin permeation rate/globulin permeation rate&#x3e;0.2 . &#x2003;&#x2003;(2)

Microporous hydrophilic membrane

A multilayer microporous membrane containing a thermoplastic resin, comprising a coarse structure layer with a higher open pore ratio and a fine structure layer with a lower open pore ratio, wherein said coarse structure layer is present at least in one membrane surface having a thickness of not less than 5.0 &#x3bc;m, a thickness of said fine structure layer is not less than 50% of the whole membrane thickness, and said coarse structure layer and said fine structure layer are formed in one-piece.

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Tokyo, Japan

Ichiro Koguma