Sankyo Company, Limited

Marubeni Kabushikigaisha

Kabushikigaisha Toyo Seisakusho

Ichiro Kawashima

Tohru Takahashi

Nobufusa Serizawa

Hidehiko Furukawa

Tokio Tani

Toshinori Ohmine

Ryuta Koishi

Jun Ohsumi

Yo Takiguchi

Isao Hirano

Yo Takiguichi

Mitsuo Seki

The present invention provides expression systems for exogenous polypeptides wherein the polypeptide is expressed as a fusion protein together with clover yellow virus Nuclear Inclusion a (NIa), the NIa component serving to autolyze the fusion protein after expression. This system can be used to express a novel polypeptide which we have designated KM31-7 protein and which is capable of reducing dichloroindophenol and reduced glutathione. This polypeptide is useful in the treatment of disorders caused by oxidative stress.

Expression systems utilizing autolyzing fusion proteins and a novel reducing polypeptide

Expression systems utilizing autolyzing fusion proteins and a reducing

Human pancreatic elastase can now be obtained from a genetically engineered source.

Human pancreatic elastase

Human pancreatic elastase I can be obtained by genetic engineering.

Human pancreatic elastase I

An artificial snowfall system comprises a snowfall room (2) in which are properly disposed a snow catching element (4) made of materials excellent in gas permeability and an atomizer unit (8) for ejecting atomized particles of liquid into the room (2). The atomized particles are frozen by heat exchange with ambient air within the room (2). The ambient air is kept at a temperature of below a freezing point of the liquid and forms an air flow passing through the snow catching element (4). The air flow causes the frozen particles to be deposited on one side of the catching element (4) to form a snow layer thereon. A beater element (9) for beating the other side of the catching element (4) is oppositely disposed from the other side to have the snow layer separated from the catching element (4). The thus separated snow layer creates artificial snowfall in the room (2).

Artificial snowfall system

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Tokyo, Japan

Ichiro Kawashima