Other

Mazda Motor Corporation

Takeda Chemical Industries, Inc.

Dainippon Ink and Chemicals, Incorporated

Fuji Photo Film Company, Limited

Daiichi Seiyaku Co., Ltd.

Murata Kikai Kabushiki Kaisha

Takara Shuzo Co., Inc.

Dainippon Sumitomo Pharma Co., Ltd.

Ichiro Azuma

Yuichi Yamamura

Yoshiaki Marutani

Kazuhi Koga

Goro Iwamura

Hiroyuki Uemura

Shigeki Matsui

Seiichi Tokura

Shinji Sasaki

Ikuo Saiki

Naoyuki Nishikawa

Akira Hasegawa

Masayoshi Kojima

Shigeru Kobayashi

Hiroyuki Komazawa

Atsushi Orikasa

Norio Nishi

Ikunoshin Kato

Mitsunori Ono

Hideto Mori

Hiroshi Kitaguchi

Isuke Imada

Tadamitsu Nakahama

Masazumi Watanabe

Shinichiro Nishimura

Hiroshi Morimoto

Tetsuo Shiba

Fusao Kimizuka

Mika Ohsawa

Hideaki Satoh

Takashi Tomita

Akira Hayashi

Shoichi Kusumoto

Tsuneo Kusama

Yoh'ichi Ohdate

Shouichi Goto

Yuki Taguchi

Yasutoshi Kawase

Tadamasa Hirayama

Hiroshi Seo

Kumao Toyoshima

Norio Hamamatsu

Kazuhisa Sugimura

Toshio Fujinaga

Katsusuke Ennyu

Osamu Aoki

An oil-in-water emulsion that comprise a bacterial component as an active ingredient as well as essentially an oil, surfactant, and a stabilizer, and that can be used as an agent for immunotherapy, and the preparation therefor are provided.

Preparations for immunotherapy for cancer having bacterial somatic constituent as the active ingredient

An agent for cancer immunotherapy with independent use, containing bacterial components as an active ingredient, which induces cancer patients to exhibit immune responsiveness, as indicated by the increase of interferon-&ggr; and CD28 markers in peripheral blood, when administered to an immuno-competent patient intracutaneously.

Immunotherapeutic agent for cancer containing nucleoidal component of bacterium as active ingredient

The present invention provides a curable resin composition incorporating an oligomer containing blocked hydroxyl group, an epoxy-group containing compound, hydrolytic silyl-group containing compound, and a dissociation catalyst and/or curing catalyst, each possessing a specific molecular weight; a paint which uses this resin composition as a binder; and a coat-finishing method which coat-finishes any desired material using the aforementioned resin composition and paint. According to the present invention, it is possible to reduce viscosity, and consequently increase the coat non-volatile content and hence improve acid resistance, abrasion resistance, and the like. In addition, according to the present invention, it is possible to obtain a curable resin composition, paint using this curable resin composition, and coat-finishing method for this paint in which the aforementioned resin and paint have an extremely high utility and possess a high solid content wherein air bubbles and drip-runs are not generated.

Curable resin composition, paint using the same, and coat-finishing

There are disclosed a high solids content resin composition excellent in solubility in an organic solvent, comprising an acrylic oligomer having a blocked hydroxyl group, a curing agent having a reactivity with a hydroxyl group and a dissociation or curing catalyst, and a high solids content type paint using the resin composition. There are also disclosed a coating process and a baking process comprising coating and baking the resin composition or the paint while rotating a material to be coated at an appropriate speed. The resin composition and the paint of the present invention have substantially no sagging and solvent popping. Further, the thus obtained paint film have improved smoothness, solvent resistance, weather resistance and resistance to scratching.

High solids content resin composition, high solids content type paint,

There are disclosed amino acid derivatives represented by the following general formula (I): ##STR1## wherein L.sup.1 and L.sup.2 represent an amino acid residue etc., A.sup.1 and A.sup.3 represent C.dbd.O, A.sup.2 represents an alkylene group etc., m and n represent an integer of 1 to 5, V represents --NHC(.dbd.NH)NH.sub.2 etc., W represents --COOH etc., R.sup.1 and R.sup.2 represent hydrogen atom, alkyl group etc., R.sup.3 and R.sup.4 represent hydrogen etc. and X and Y represent --NH-- or --O-- and pharmaceutically acceptable salts thereof and agents for inhibiting tumor matastasis containing the compounds, and the amino acid derivatives exhibit high activity for inhibiting tumor metastasis and weak platelet aggregation inhibition activity and weak anticoagulation activity.

Amino acid derivatives and application thereof

A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;

Tumor metastasis inhibiting compounds and methods

A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:

Polypeptide comprising repeated cell-adhesive core sequences

This invention relates to a functional polypeptide containing the binding domain of human fibronectin and the heparin-binding domain of human fibronectin.

Functional polypeptide containing a cell binding domain and a heparin

A slow-releasing preparation comprises porous granules of deacetylated chitin as a carrier and a physiologically active substance contained in the granules. The slow-releasing prepartion can be embedded in a body for curing diseases.

Slow-releasing preparation

Muramyldipeptide derivatives represented by the formula: ##STR1## wherein Ala represents alanine; Acyl represents an acyl group; R.sub.1 and R.sub.2 each represents a hydrogen atom or, when taken together, may form an alkylidene group; R.sub.3 represents a hydrogen atom, an acyl group or an alkyl group; and R.sub.4 represents a hydrogen atom or an alkyl group. These compounds have excellent immunoadjuvant activity, prophylactic and therapeutic effects against microbial infections, and antitumor activity.

Muramyldipeptide derivatives

A stable, storable pharmaceutical composition is provided which comprises a dehydrated solid mixture of microbial cell wall skeleton, vehicle oil, suspending agent and dispersing agent; wherein said microbial cell wall skeleton has adjuvant and antitumor activity. The composition is easily prepared, stable to long term storage, and easily reconstituted to form a homogeneous suspension which retains high potency.

Solidified pharmaceutical composition comprising cell wall skeleton

Novel glucosamine-peptide derivatives of the formula: ##STR1## wherein m is 0 or 1;

Glucosamine peptide derivatives, their production and use

Novel 6-deoxyglucosamine-peptide derivatives of the formula ##STR1## wherein R is hydrogen or an organic acid residue or alkoxycarbonyl;

6-Deoxyglucosamine-peptide derivatives, their production and use

Growing community of inventors

Sapporo, Japan

Ichiro Azuma